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1. WO2021213498 - MOUSE MODEL HAVING KNOCKED-IN HUMAN ACE2 GENE, PRODUCTION METHOD THEREFOR AND USE THEREOF

Publication Number WO/2021/213498
Publication Date 28.10.2021
International Application No. PCT/CN2021/089243
International Filing Date 23.04.2021
IPC
C12N 15/89 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
89using microinjection
C12N 15/877 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
873Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
877Techniques for producing new mammalian cloned embryos
A01K 67/027 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
CPC
A01K 67/027
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
C12N 15/877
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
873Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
877Techniques for producing new mammalian cloned embryos
C12N 15/89
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
89using microinjection
Applicants
  • 中国食品药品检定研究院 NATIONAL INSTITUTE FOR FOOD AND DRUG CONTROL [CN]/[CN]
  • 中国人民解放军军事科学院军事医学研究院 ACADEMY OF MILITARY MEDICAL SCIENCES (AMMS) [CN]/[CN]
Inventors
  • 范昌发 FAN, Changfa
  • 秦成峰 QIN, Chengfeng
  • 王佑春 WANG, Youchun
  • 周育森 ZHOU, Yusen
Agents
  • 北京市中咨律师事务所 ZHONGZI LAW OFFICE
Priority Data
202010334250.424.04.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) MOUSE MODEL HAVING KNOCKED-IN HUMAN ACE2 GENE, PRODUCTION METHOD THEREFOR AND USE THEREOF
(FR) MODÈLE DE SOURIS AYANT UN GÈNE AC2 HUMAIN ACTIVÉ, PROCÉDÉ DE PRODUCTION S'Y RAPPORTANT ET UTILISATION CORRESPONDANTE
(ZH) 人ACE2基因敲入的小鼠模型、其产生方法和用途
Abstract
(EN) Provided are a mouse having a human ACE2 gene knocked in a genome, a production method therefor and a use thereof in evaluating the in-vivo efficacy of antiviral agents and vaccines against SARS-CoV-2. Human ACE2 is accurately inserted into the place of mACE2 gene in a mouse genome, establishing a novel knock-in mouse model having the human ACE2 gene at the place of the mACE2 gene.
(FR) L'invention concerne une souris ayant un gène ACE2 humain activé dans un génome, un procédé de production s'y rapportant et une utilisation correspondante dans l'évaluation de l'efficacité in vivo d'agents antiviraux et de vaccins contre le SARS-CoV-2. Le gène ACE2 humain est inséré avec précision à la place du gène mACE2 dans un génome de souris, établissant un nouveau modèle de souris activé ayant le gène ACE2 humain à la place du gène mACE2.
(ZH) 提供了基因组中敲入了人ACE2基因的小鼠、其产生方法和其在用于评估抗SARS-CoV-2的抗病毒剂和疫苗的体内功效中的用途。将人ACE2准确插入到小鼠基因组中mACE2基因处,建立了在mACE2基因处人ACE2基因的新型敲入小鼠模型。
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