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1. WO2021207517 - MODIFIED HR2 PEPTIDE INHIBITORS OF CORONAVIRUS FUSION

Publication Number WO/2021/207517
Publication Date 14.10.2021
International Application No. PCT/US2021/026416
International Filing Date 08.04.2021
IPC
A61K 38/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61P 31/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
C07K 14/005 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C07K 19/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
CPC
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C12N 2770/20022
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
20011Coronaviridae
20022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
C12N 2770/20033
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
20011Coronaviridae
20033Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
Applicants
  • SAPIENCE THERAPEUTICS, INC. [US]/[US]
Inventors
  • MERUTKA, Gene
Agents
  • YVON, Anne-Marie C.
Priority Data
63/008,46910.04.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MODIFIED HR2 PEPTIDE INHIBITORS OF CORONAVIRUS FUSION
(FR) INHIBITEURS DE PEPTIDE HR2 MODIFIÉS DE LA FUSION DU CORONAVIRUS
Abstract
(EN) Provided are modified HR2 peptides that are capable of competing with the native HR2 region of a viral spike (S) protein for binding to the HR1 region, thereby inhibiting formation of the 6-HB fusion complex and fusion with a target host cell, compositions comprising the modified HR2 peptides, and methods of inhibiting viral fusion using the HR2 peptides.
(FR) L'invention concerne des peptides HR2 modifiés qui sont capables de concurrencer la région HR2 native d'une protéine de spicule (S) virale pour se lier à la région HR1, ce qui permet d'inhiber la formation du complexe de fusion 6-HB et de fusionner avec une cellule hôte cible, des compositions comprenant les peptides HR2 modifiés, et des procédés d'inhibition de la fusion virale à l'aide des peptides HR2.
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