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1. WO2021204985 - USE OF VIDOFLUDIMUS FOR THE TREATMENT OF CORONAVIRUS INFECTIONS

Publication Number WO/2021/204985
Publication Date 14.10.2021
International Application No. PCT/EP2021/059266
International Filing Date 09.04.2021
IPC
A61K 31/192 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
192having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61P 31/20 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
CPC
A61K 31/192
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
192having aromatic groups, e.g. sulindac, 2-arylpropionic acids, ethacrynic acid
A61P 31/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
Applicants
  • INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) [FR]/[FR]
  • UNIVERSITÉ D'AIX MARSEILLE [FR]/[FR]
  • ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE [FR]/[FR]
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) [FR]/[FR]
  • ECOLE NORMALE SUPÉRIEURE DE LYON [FR]/[FR]
  • INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD) [FR]/[FR]
  • UNIVERSITÉ CLAUDE BERNARD - LYON 1 [FR]/[FR]
Inventors
  • VIDALAIN, Pierre-Olivier
  • LOTTEAU, Vincent
  • ANDRE, Patrice
  • TOURET, Franck
  • DE LAMBALLERIE, Xavier Nicolas
  • NOUGAIREDE, Antoine
Agents
  • INSERM TRANSFERT
Priority Data
20315150.110.04.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) USE OF VIDOFLUDIMUS FOR THE TREATMENT OF CORONAVIRUS INFECTIONS
(FR) UTILISATION DE VIDOFLUDIMUS DANS LE TRAITEMENT DES INFECTIONS À CORONAVIRUS
Abstract
(EN) Coronaviridae is a family of enveloped, positive-sense, single-stranded RNA viruses. The emergence of a new betacoronavirus SARS-CoV-2 has led to a major health-related crisis associated with a significant mortality in intensive care units, due to the pulmonary complications of COVID-19. The inventors showed that Vidofludimus is suitable for inhibiting replication of coronavirus and thus would be suitable for the treatment of infections mediated by said type of virus.
(FR) La Coronaviridae est une famille de virus à ARN simple brin, à sens positif, enveloppés. L’émergence d’un nouveau bêtacoronavirus SARS-CoV-2 a conduit à une crise sanitaire majeure associée à une mortalité conidérable dans les unités de soins intensifs, due aux complications pulmonaires de la COVID-19. Les inventeurs ont montré que le Vidofludimus convient pour inhiber la réplication du coronavirus et ainsi pourrait convenir au traitement d’infections à médiation par ledit type de virus.
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