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1. WO2021164789 - CRYSTAL FORM OF PYRAZOLOPYRIMIDINE COMPOUND AND USE THEREOF

Publication Number WO/2021/164789
Publication Date 26.08.2021
International Application No. PCT/CN2021/077255
International Filing Date 22.02.2021
IPC
C07D 487/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/519 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
CPC
A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • 南京明德新药研发有限公司 MEDSHINE DISCOVERY INC. [CN]/[CN]
Inventors
  • 黄婧婕 HUANG, Jingjie
  • 谭冶 TAN, Ye
  • 王彦斌 WANG, Yanbin
  • 姚婷 YAO, Ting
  • 于涛 YU, Tao
  • 吴成德 WU, Chengde
Agents
  • 上海弼兴律师事务所 SHANGHAI BESHINING LAW OFFICE
Priority Data
202010110671.921.02.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) CRYSTAL FORM OF PYRAZOLOPYRIMIDINE COMPOUND AND USE THEREOF
(FR) FORME CRISTALLINE D'UN COMPOSÉ DE PYRAZOLOPYRIMIDINE ET SON UTILISATION
(ZH) 一种吡唑并嘧啶类化合物的晶型及其应用
Abstract
(EN) Disclosed in the present invention are a crystal form of a pyrazolopyrimidine compound and a preparation method therefor. Furthermore, the present invention relates to the use of the compound in the preparation of drugs for treating diseases related to chronic lymphocytic leukemia, small lymphocytic lymphoma, marginal zone lymphoma, follicular lymphoma, mantle cell lymphoma, and diffuse large B-cell lymphoma.
(FR) La présente invention concerne une forme cristalline d'un composé de pyrazolopyrimidine et son procédé de préparation. En outre, la présente invention concerne l'utilisation dudit composé dans la préparation de médicaments pour le traitement de maladies en rapport avec la leucémie lymphoïde chronique, le lymphome à petits lympocytes, le lymphome de la zone marginale, le lymphome folliculaire, le lymphome à cellules du manteau et le lymphome diffus à grandes cellules B.
(ZH) 本发明公开了一种吡唑并嘧啶类化合物的晶型及其制备方法,并涉及其在制备治疗慢性淋巴细胞白血病、小淋巴细胞淋巴瘤、边缘带淋巴瘤、滤泡性淋巴瘤、套细胞淋巴瘤和弥漫性大B细胞淋巴瘤相关疾病的药物中的应用。
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