1. WO2021160654 - NANOMATERIALS COATED WITH CALIXARENES

Publication Number WO/2021/160654

Publication Date 19.08.2021

International Application No. PCT/EP2021/053170

International Filing Date 10.02.2021

IPC

C07C 217/94 2006.1

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
217	Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
78	having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
94	having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton

C07C 245/20 2006.1

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
245	Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
20	Diazonium compounds

C07D 333/50 2006.1

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
333	Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
50	condensed with carbocyclic rings or ring systems

C08J 7/04 2020.1

C	CHEMISTRY; METALLURGY
08	ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
J	WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H142
7	Chemical treatment or coating of shaped articles made of macromolecular substances
04	Coating

A61K 47/58 2017.1

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
56	the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
58	obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyacrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin

A61K 47/62 2017.1

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
62	the modifying agent being a protein, peptide or polyamino acid

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C07C 217/94 2006.1

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
217	Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
78	having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
94	having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton

C07C 245/20 2006.1

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
245	Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
20	Diazonium compounds

C07D 333/50 2006.1

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
333	Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
50	condensed with carbocyclic rings or ring systems

C08J 7/04 2020.1

C	CHEMISTRY; METALLURGY
08	ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
J	WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H142
7	Chemical treatment or coating of shaped articles made of macromolecular substances
04	Coating

A61K 47/58 2017.1

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
56	the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
58	obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyacrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin

A61K 47/62 2017.1

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
62	the modifying agent being a protein, peptide or polyamino acid

A61K 47/69 2017.1

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69	the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

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CPC

B22F 1/054

B22F 1/0545

B22F 1/102

B22F 9/24

B	PERFORMING OPERATIONS; TRANSPORTING
22	CASTING; POWDER METALLURGY
F	WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER
9	Making metallic powder or suspensions thereof
16	using chemical processes
18	with reduction of metal compounds
24	starting from liquid metal compounds, e.g. solutions

B82Y 40/00

B	PERFORMING OPERATIONS; TRANSPORTING
82	NANOTECHNOLOGY
Y	SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
40	Manufacture or treatment of nanostructures

B82Y 5/00

B	PERFORMING OPERATIONS; TRANSPORTING
82	NANOTECHNOLOGY
Y	SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
5	Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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B22F 1/054

B22F 1/0545

B22F 1/102

B22F 9/24

B	PERFORMING OPERATIONS; TRANSPORTING
22	CASTING; POWDER METALLURGY
F	WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER
9	Making metallic powder or suspensions thereof
16	using chemical processes
18	with reduction of metal compounds
24	starting from liquid metal compounds, e.g. solutions

B82Y 40/00

B	PERFORMING OPERATIONS; TRANSPORTING
82	NANOTECHNOLOGY
Y	SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
40	Manufacture or treatment of nanostructures

B82Y 5/00

B	PERFORMING OPERATIONS; TRANSPORTING
82	NANOTECHNOLOGY
Y	SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
5	Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

C07C 213/02

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
213	Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
02	by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups

C07C 245/20

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
245	Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
20	Diazonium compounds

C07F 1/00

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
1	Compounds containing elements of Groups 1 or 11 of the Periodic System

C07F 1/08

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
1	Compounds containing elements of Groups 1 or 11 of the Periodic System
08	Copper compounds

C07F 15/006

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
15	Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
0006	compounds of the platinum group
006	Palladium compounds

C07F 15/0086

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
15	Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
0006	compounds of the platinum group
0086	Platinum compounds

C07F 15/02

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
15	Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
02	Iron compounds

G01N 33/56983

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48	Biological material, e.g. blood, urine
50	Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53	Immunoassay; Biospecific binding assay; Materials therefor
569	for microorganisms, e.g. protozoa, bacteria, viruses
56983	Viruses

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Applicants

• UNIVERSITE LIBRE DE BRUXELLES [BE]/[BE]

Inventors

• BRUYLANTS, Gilles
• JABIN, Ivan
• RETOUT, Maurice
• GOSSELIN, Bryan

Agents

• KIRKPATRICK

Priority Data

20156678.3		11.02.2020		EP
20205365.8		03.11.2020		EP

Publication Language English (en)

Filing Language English (en)

Designated States

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AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, IT, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, WS, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)

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Title

(EN) NANOMATERIALS COATED WITH CALIXARENES

(FR) NANOMATÉRIAUX REVÊTUS DE CALIXARÈNES

Abstract

(EN) This invention concerns a versatile and simple one-pot method to prepare nanomaterials, and in particular nanoparticles, grafted with an ultra-thin layer of calixarenes by placing at 5 least one oxidized metal with at least one calix[n]arene diazonium salt in the presence of a reducing agent in a solvent, and heating the reaction mixture to obtain a metal-based nanomaterial coated with calix[n]arenes. The invention further concerns the coupling of organic molecules or biomolecules to the calixarene-grafted nanomaterials in order to further functionalize the surface of the particles. The metal-based nanomaterial coated with 10 calix[n]arenes can for example be used in immunoassays.

(FR) La présente invention concerne un procédé monotope polyvalent et simple destiné à la préparation de nanomatériaux, et en particulier des nanoparticules, greffés avec une couche ultra-mince de calixarènes par la mise en place d'au moins un métal oxydé avec au moins un sel de calix[n]arène diazonium en présence d'un agent réducteur dans un solvant, et le chauffage du mélange réactionnel pour obtenir un nanomatériau à base de métal revêtu de calix[n]arènes. L'invention concerne en outre le couplage de molécules ou de biomolécules organiques aux nanomatériaux greffés au calixarène afin de fonctionnaliser encore la surface des particules. Le nanomatériau à base de métal revêtu de 10 calix[n]arènes peut par exemple être utilisé dans des dosages immunologiques.

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