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1. WO2021153690 - NOVEL CRYSTAL FORM OF BENZENE DERIVATIVE

Publication Number WO/2021/153690
Publication Date 05.08.2021
International Application No. PCT/JP2021/003092
International Filing Date 28.01.2021
IPC
A61P 25/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
C07C 311/21 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
311Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
21having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
A61K 31/192 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
192having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
CPC
A61K 31/192
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
192having aromatic groups, e.g. sulindac, 2-arylpropionic acids, ethacrynic acid
A61P 25/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
C07C 311/21
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
311Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
21having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
Applicants
  • 小野薬品工業株式会社 ONO PHARMACEUTICAL CO., LTD. [JP]/[JP]
Inventors
  • 大谷 修平 OHTANI, Shuhei
  • 藤戸 貴之 FUJITO, Takayuki
  • 西馬 直希 NISHIUMA, Naoki
Agents
  • 青木 篤 AOKI, Atsushi
  • 三橋 真二 MITSUHASHI, Shinji
  • 渡辺 陽一 WATANABE, Yoichi
  • 中島 勝 NAKAJIMA, Masaru
  • 武居 良太郎 TAKEI, Ryotaro
  • 中村 和美 NAKAMURA, Kazumi
Priority Data
2020-01207529.01.2020JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) NOVEL CRYSTAL FORM OF BENZENE DERIVATIVE
(FR) NOUVELLE FORME CRISTALLINE DE DÉRIVÉ DU BENZÈNE
(JA) ベンゼン誘導体の新規結晶形
Abstract
(EN) A compound according to the present invention has a strong neuroprotective action and/or a neurorepair action, and therefore can serve as a therapeutic agent for neurological disorders (e.g., chronic inflammatory demyelinating polyneuritis, Guillain-Barre syndrome, periarteritis nodosa, allergic angiitis, diabetic peripheral neuropathy, entrapment syndrome, peripheral neuropathy associated with administration of chemotherapy medication, and peripheral neuropathy associated with Charcot-Marie-Tooth disease). Moreover, the crystals of the compound have excellent handling properties as a bulk drug substance.
(FR) Un composé selon la présente invention présente une forte action neuroprotectrice et/ou une action neuroréparatrice, et peut par conséquent servir d'agent thérapeutique pour des troubles neurologiques (par exemple, la polynévrite démyélinisante inflammatoire chronique, le syndrome de Guillain-Barré, la périartérite noueuse, l'angéite allergique, la neuropathie périphérique diabétique, le syndrome de compression, la neuropathie périphérique associée à l'administration d'un médicament de chimiothérapie, et la neuropathie périphérique associée à la maladie de Charcot-Marie-Tooth). De plus, les cristaux du composé ont d'excellentes propriétés de manipulation en tant que substance médicamenteuse en vrac.
(JA) 本発明化合物は、強力な神経保護および/または修復作用を有することから、神経障害(例えば、慢性炎症性脱髄性多発神経炎、ギランバレー症候群、結節性動脈周囲炎、アレルギー性血管炎、糖尿病性末梢神経障害、絞扼性神経障害、化学療法薬投与に伴う末梢神経障害、またはシャルコー・マリー・トゥース病に伴う末梢神経障害など)の治療剤となり得、またその結晶は医薬品原薬として取扱いに優れる。
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