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1. WO2021105234 - COMPOSITIONS FOR REPROGRAMMING CELLS INTO DENDRITIC CELLS TYPE 2 COMPETENT FOR ANTIGEN PRESENTATION, METHODS AND USES THEREOF

Publication Number WO/2021/105234
Publication Date 03.06.2021
International Application No. PCT/EP2020/083400
International Filing Date 25.11.2020
Chapter 2 Demand Filed 21.09.2021
IPC
C12N 5/0784 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0784Dendritic cells; Progenitors thereof
A61K 35/15 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
15Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
CPC
A61K 35/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
A61K 35/38
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
37Digestive system
38Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
A61K 35/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
48Reproductive organs
54Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
545Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
A61K 9/0019
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
C12N 15/86
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
C12N 2506/1307
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2506Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
13from connective tissue cells, from mesenchymal cells
1307from adult fibroblasts
Applicants
  • ASGARD THERAPEUTICS AB
Inventors
  • RIBEIRO LEMOS PEREIRA, Carlos, Filipe
  • FERREIRA, PIRES, Cristiana
  • FIÚZA, ROSA, Fábio
  • OLIVEIRA, Luís, Filipe, Henriques
Agents
  • HØIBERG P/S
Priority Data
11593325.11.2019PT
20190159.207.08.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS FOR REPROGRAMMING CELLS INTO DENDRITIC CELLS TYPE 2 COMPETENT FOR ANTIGEN PRESENTATION, METHODS AND USES THEREOF
(FR) COMPOSITIONS DESTINÉES À LA REPROGRAMMATION DE CELLULES EN CELLULES DENDRITIQUES DE TYPE 2 APPROPRIÉES POUR LA PRÉSENTATION D'ANTIGÈNE, PROCÉDÉS ET UTILISATIONS ASSOCIÉS
Abstract
(EN) The present disclosure relates to compositions for reprogramming cells into conventional dendritic cells (cDC), particularly into cDC type 2 (hereinafter referred to as "cDC2" or "CD11b-positive dendritic cells"), methods and uses thereof. The present disclosure relates to the development of methods for making conventional dendritic cells with antigen presenting capacity from differentiated, multipotent or pluripotent stem cells by introducing and expressing isolated/synthetic transcription factors. More particularly, the disclosure provides methods for obtaining conventional dendritic cells (cDC), particularly cDC type 2 or CD11b-positive dendritic cells, by direct cell reprogramming with the surprisingly use of combinations of specific transcription factors.
(FR) La présente invention concerne des compositions pour la reprogrammation de cellules en cellules dendritiques classiques (cDC), en particulier dans des cDC de type 2 (ci-après désignées par « cDC2 » ou « cellules dendritiques positives à CD11b »), des procédés et des utilisations associés. La présente invention concerne le développement de procédés de fabrication de cellules dendritiques classiques avec des capacités de présentation d'antigène à partir de cellules souches différenciées, multipotentes ou pluripotentes par introduction et expression de facteurs de transcription isolés/synthétiques. Plus particulièrement, l'invention concerne des procédés pour obtenir des cellules dendritiques classiques (cDC), particulièrement des cDC de type 2 ou des cellules dendritiques positives à CD11b par reprogrammation cellulaire directe avec l'utilisation contre tout attente de combinaisons de facteurs de transcription spécifiques.
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