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1. WO2021092254 - PHAGE COMPOSITIONS COMPRISING CRISPR-CAS SYSTEMS AND METHODS OF USE THEREOF

Publication Number WO/2021/092254
Publication Date 14.05.2021
International Application No. PCT/US2020/059218
International Filing Date 05.11.2020
IPC
A61K 31/7088 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61K 31/713 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
713Double-stranded nucleic acids or oligonucleotides
A61K 35/74 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
A61K 35/76 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
Applicants
  • LOCUS BIOSCIENCES, INC. [US]/[US]
Inventors
  • OUSTEROUT, David G.
  • SELLE, Kurt
Agents
  • BOYLE ANDERSON, Erin
Priority Data
62/931,79706.11.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PHAGE COMPOSITIONS COMPRISING CRISPR-CAS SYSTEMS AND METHODS OF USE THEREOF
(FR) COMPOSITIONS DE PHAGE COMPRENANT LES SYSTÈMES CRISPR-CAS ET LEURS PROCÉDÉS D’UTILISATION
Abstract
(EN)
Disclosed here are phage compositions comprising Type I CRISPR-Cas systems and methods of use thereof. In some embodiments, disclosed herein is a nucleic acid sequence comprising (a) a first CRISPR array designed to be operable with a first Type I CRISPR-Cas system, and (b) a second CRISPR array designed to be operable with a second Type I CRISPR-Cas system, wherein the first Type I CRISPR-Cas system and the second Type I CRISPR-Cas system are different Type I CRISPR-Cas systems.
(FR)
La présente invention concerne des compositions de phage comprenant des systèmes CRISPR-Cas de type I et leurs procédés d’utilisation. Dans certains modes de réalisation, la présente invention est une séquence d’acides nucléiques comprenant (a) un premier réseau CRISPR conçu pour pouvoir fonctionner avec un premier système CRISPR-Cas de type I, et (b) un second réseau CRISPR conçu pour pouvoir fonctionner avec un second système CRISPR-Cas de type I, le premier système CRISPR-Cas de type I et le second système CRISPR-Cas de type I étant différents systèmes CRISPR-Cas de type I.
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