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1. WO2021092143 - MICRORNA BLOCKADE FOR THE TREATMENT OF DISEASE

Publication Number WO/2021/092143
Publication Date 14.05.2021
International Application No. PCT/US2020/059065
International Filing Date 05.11.2020
IPC
A61K 31/7088 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
C07H 21/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C07H 21/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02with ribosyl as saccharide radical
C12N 5/06 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
06Animal cells or tissues
Applicants
  • YALE UNIVERSITY [US]/[US]
Inventors
  • BENDER, Jeffrey
  • RAMGOLAM, Vinod
  • YAROVINSKY, Timur
Agents
  • DOYLE, Kathryn
  • LANDRY, Brian
  • SILVA, Domingos
  • SIMPSON, Mark
  • CROTTY, Justin
  • YOUNG, Jacque
  • BROWNING, Elizabeth
  • OSTROVSKY, Dennis
Priority Data
62/932,20507.11.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MICRORNA BLOCKADE FOR THE TREATMENT OF DISEASE
(FR) BLOCAGE DE MICROARN POUR LE TRAITEMENT D'UNE MALADIE
Abstract
(EN)
In various aspects and embodiments the invention provides compositions and methods useful in the treatment of disease. In one aspect the invention provides a composition comprising a polynucleotide comprising one or more of SEQ ID NOS: 1-41 and at least one modification selected from the group consisting of locked nucleic acid, bridged nucleic acid, phosphorothioate nucleic acid, and peptide nucleic acid.
(FR)
Dans divers aspects et modes de réalisation, l'invention concerne des compositions et des méthodes utiles dans le traitement d'une maladie. Dans un aspect, l'invention concerne une composition comprenant un polynucléotide comprenant une ou plusieurs des SEQ ID NO : 1 à 41 et au moins une modification choisie dans le groupe constitué par un acide nucléique bloqué, un acide nucléique ponté, un acide nucléique phosphorothioate et un acide nucléique peptidique.
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