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1. WO2021092095 - NEOANTIGEN VACCINE THERAPY

Publication Number WO/2021/092095
Publication Date 14.05.2021
International Application No. PCT/US2020/058983
International Filing Date 04.11.2020
IPC
A61K 35/76 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
C07K 14/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
18Togaviridae, e.g. flavivirus, pestivirus, yellow fever virus, hepatitis C virus, japanese encephalitis virus
C12N 15/86 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
Applicants
  • GRITSTONE BIO, INC. [US]/[US]
Inventors
  • FERGUSON, Andrew
  • ROUSSEAU, Raphael
  • YELENSKY, Roman
  • SUN, James Xin
  • DAVIS, Matthew Joseph
  • JOOSS, Karin
  • RAPPAPORT, Amy Rachel
  • SCALLAN, Ciaran Daniel
  • GITLIN, Leonid
  • PALMER, Christine Denise
  • BUSBY, Jennifer
  • BULIK-SULLIVAN, Brendan
  • SKOBERNE, Mojca
  • BLAIR, Wade
Agents
  • NEWMAN, Zachary R.
  • SHUSTER, Michael, J.
  • HURT, Nicholas, S.
  • HUBL, Susan
  • KABLER, Kevin
Priority Data
62/930,46004.11.2019US
62/946,95611.12.2019US
62/959,79810.01.2020US
63/051,22713.07.2020US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NEOANTIGEN VACCINE THERAPY
(FR) VACCINOTHÉRAPIE AVEC DES NÉO-ANTIGÈNES
Abstract
(EN)
Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccination strategy.
(FR)
L'invention concerne des compositions qui contiennent des peptides antigéniques et/ou des séquences d'acide nucléique codant pour des antigènes. L'invention concerne également des nucléotides, des cellules et des méthodes associées à ces compositions, y compris leur utilisation en tant que vaccins, y compris des vecteurs et des méthodes pour une stratégie hétérologue de vaccination de primo-immunisation/rappel.
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