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1. WO2021092047 - METHODS OF GENERATING ENUCLEATED ERYTHROID CELLS USING TAURINE OR HYPOTAURINE

Publication Number WO/2021/092047
Publication Date 14.05.2021
International Application No. PCT/US2020/058930
International Filing Date 04.11.2020
IPC
C12N 5/078 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
CPC
A61K 35/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
18Erythrocytes
C12N 2500/25
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2500Specific components of cell culture medium
05Inorganic components
10Metals; Metal chelators
20Transition metals
24Iron; Fe chelators; Transferrin
25Insulin-transferrin; Insulin-transferrin-selenium
C12N 2500/33
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2500Specific components of cell culture medium
30Organic components
32Amino acids
33other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
C12N 2500/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2500Specific components of cell culture medium
30Organic components
34Sugars
C12N 2500/84
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2500Specific components of cell culture medium
70Undefined extracts
80from animals
84from mammals
C12N 2501/125
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2501Active agents used in cell culture processes, e.g. differentation
10Growth factors
125Stem cell factor [SCF], c-kit ligand [KL]
Applicants
  • RUBIUS THERAPEUTICS, INC. [US]/[US]
Inventors
  • LAW, Billy
  • GILBERT, Alan Benjamin
Agents
  • REITER, Tiffany
  • XING, Liujing
Priority Data
62/930,52804.11.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF GENERATING ENUCLEATED ERYTHROID CELLS USING TAURINE OR HYPOTAURINE
(FR) PROCÉDÉS DE GÉNÉRATION DE CELLULES ÉRYTHROÏDES ÉNUCLÉÉES À L'AIDE DE TAURINE OU D'HYPOTAURINE
Abstract
(EN)
Provided herein are methods of generating a population of enucleated erythroid cells.
(FR)
L'invention concerne des porécédés de génération d'une population de cellules érythroïdes énucléées.
Also published as
Latest bibliographic data on file with the International Bureau