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1. WO2021091316 - COMPOSITION, COMPRISING TMEM176B OR AN EXPRESSION OR ACTIVITY REGULATOR THEREOF AS AN ACTIVE INGREDIENT, FOR PREVENTION OR TREATMENT OF DEGENERATIVE BRAIN DISEASE

Publication Number WO/2021/091316
Publication Date 14.05.2021
International Application No. PCT/KR2020/015530
International Filing Date 06.11.2020
IPC
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 31/4422 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
44221,4-Dihydropyridines, e.g. nifedipine, nicardipine
A61P 25/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 25/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
Applicants
  • 아밀로이드솔루션 주식회사 AMYLOID SOLUTION INC. [KR]/[KR]
Inventors
  • 김정환 KIM, Junghwan
  • 박상훈 PARK, Sanghoon
  • 박성정 PARK, Seongjeong
  • 김혜주 KIM, Hye-Ju
Agents
  • 특허법인더웨이브 THE WAVE IP LAW FIRM
Priority Data
10-2019-014192707.11.2019KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION, COMPRISING TMEM176B OR AN EXPRESSION OR ACTIVITY REGULATOR THEREOF AS AN ACTIVE INGREDIENT, FOR PREVENTION OR TREATMENT OF DEGENERATIVE BRAIN DISEASE
(FR) COMPOSITION, COMPRENANT DU TMEM176B, OU UN RÉGULATEUR D'EXPRESSION OU D'ACTIVITÉ ASSOCIÉ, UTILISÉ COMME PRINCIPE ACTIF, POUR LA PRÉVENTION OU LE TRAITEMENT D'UNE MALADIE DÉGÉNÉRATIVE DU CERVEAU
(KO) TMEM176B, 이의 발현 또는 활성 조절제를 유효성분으로 포함하는 퇴행성 뇌질환 예방 또는 치료용 조성물
Abstract
(EN)
The present invention relates to a composition, comprising TMEM176B as an active ingredient, for prevention or treatment of degenerative brain disease. A composition according to an embodiment promotes the phagocytic action of astrocytes on amyloid-beta, reduces amyloid plaques, and improves behavioral and cognitive functions in Alzheimer animal models, thus finding advantageous applications in preventing and/or treating various degenerative brain diseases.
(FR)
La présente invention concerne une composition, comprenant du TMEM176B utilisé comme principe actif, pour la prévention ou le traitement d'une maladie dégénérative du cerveau. Une composition selon un mode de réalisation favorise l'action phagocytaire d'astrocytes sur l'amyloïde bêta, réduit les plaques amyloïdes et améliore les fonctions comportementales et cognitives dans des modèles animaux d'Alzheimer, trouvant ainsi des applications avantageuses dans la prévention et/ou le traitement de diverses maladies dégénératives du cerveau.
(KO)
TMEM176B를 유효성분으로 포함하는 퇴행성 뇌질환 예방 또는 치료용 조성물에 관한 것으로, 일 양상에 따른 조성물에 의하면, 별아교세포의 아밀로이드-베타의 대식작용을 촉진하고, 아밀로이드 플라크를 감소시킬 뿐만 아니라, 알츠하이머 동물 모델에서 행동 및 인지기능 개선의 효과가 있어 다양한 퇴행성 뇌질환의 예방 및/또는 치료에 유용하게 사용될 수 있는 효과가 있다.
Also published as
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