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1. WO2021091277 - BLOOD-BASED DNA METHYLATION BIOMARKER PANEL FOR DIAGNOSING COLORECTAL CANCER

Publication Number WO/2021/091277
Publication Date 14.05.2021
International Application No. PCT/KR2020/015447
International Filing Date 06.11.2020
IPC
C12Q 1/6886 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Applicants
  • 서울대학교산학협력단 SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION [KR]/[KR]
  • 주식회사 아이엠비디엑스 IMB DX, INC. [KR]/[KR]
Inventors
  • 김태유 KIM, Tae-You
  • 강경훈 KANG, Gyeong Hoon
  • 송상현 SONG, Sang-Hyun
  • 김황필 KIM, Hwang-Phill
  • 조남윤 CHO, Nam-Yun
  • 문현우 MOON, Hyunwoo
  • 문성태 MOON, Sungtae
Agents
  • 박원미 PARK, Weonmee
Priority Data
10-2019-014235508.11.2019KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) BLOOD-BASED DNA METHYLATION BIOMARKER PANEL FOR DIAGNOSING COLORECTAL CANCER
(FR) PANEL DE BIOMARQUEURS DE MÉTHYLATION DE L'ADN BASÉ SUR LE SANG PERMETTANT DE DIAGNOSTIQUER UN CANCER COLORECTAL
(KO) 혈액 기반 대장암 진단용 DNA 메틸화 바이오마커 패널
Abstract
(EN)
The present application relates to a DNA methylation biomarker panel for diagnosing colorectal cancer, the panel being capable of diagnosing colorectal cancer by detecting and measuring methylation changes of genes in the blood of a patient. The blood-based DNA methylation biomarker panel for diagnosing colorectal cancer, according to the present application, diagnoses colorectal cancer through only blood collection so as to overcome side effects and the inconvenience of having to collect a patient’s tissue, thereby enabling the burden on the patient to be minimized.
(FR)
La présente invention concerne un panel de biomarqueurs de méthylation de l'ADN permettant de diagnostiquer un cancer colorectal, le panel pouvant permettre de diagnostiquer un cancer colorectal par la détection et la mesure de changements dans la méthylation de gènes dans le sang d'un patient. Le panel de biomarqueurs de méthylation de l'ADN basé sur le sang permettant de diagnostiquer un cancer colorectal selon la présente demande permet de diagnostiquer un cancer colorectal grâce à un simple prélèvement de sang, de manière à surmonter les effets secondaires et l'inconvénient de devoir prélever un tissu du patient, ce qui permet de réduire au minimum la charge pour le patient.
(KO)
본원은 환자의 혈액 내 유전자의 메틸화 변화를 검출 및 측정하여 대장암을 진단할 수 있는 대장암 진단용 DNA 메틸화 바이오마커 패널에 관한 것이다. 본원에 따른 혈액 기반 대장암 진단용 DNA 메틸화 바이오마커 패널은 혈액 채취만으로 대장암을 진단함으로써 환자의 조직을 채취해야하는 불편함 및 부작용을 극복하여 환자의 부담을 최소화할 수 있다.
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