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1. WO2021089765 - TLR3 LIGANDS THAT ACTIVATE BOTH EPITHELIAL AND MYELOID CELLS

Publication Number WO/2021/089765
Publication Date 14.05.2021
International Application No. PCT/EP2020/081260
International Filing Date 06.11.2020
IPC
C12N 15/117 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
A61K 31/713 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
713Double-stranded nucleic acids or oligonucleotides
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/713
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
713Double-stranded nucleic acids or oligonucleotides
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/2818
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2818against CD28 or CD152
C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
C12N 15/1138
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
1138against receptors or cell surface proteins
Applicants
  • TOLLYS [FR]/[FR]
Inventors
  • BONNIN, Marc
  • THIERRY, Sylvain
Agents
  • BCF GLOBAL
Priority Data
16/675,84606.11.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TLR3 LIGANDS THAT ACTIVATE BOTH EPITHELIAL AND MYELOID CELLS
(FR) LIGANDS DE TLR3 QUI ACTIVENT À LA FOIS DES CELLULES ÉPITHÉLIALES ET MYÉLOÏDES
Abstract
(EN)
The invention relates to a composition comprising double-stranded RNAs (dsRNA) essentially consisting of dsRNA having two complementary strands, comprising at least one block or homopolymer of poly A and the complementary block or homopolymer of poly U, each block comprising at least 15, 20, 25 or 30 A, or U, each strand having a determined length of between 50 and 200 bases, preferably between 55 and 200 bases, all the strands or substantially all the strands have the determined length, and a pharmaceutically acceptable vehicle, carrier or excipient. The composition may be used in treating Non Muscle Invasive Bladder Cancer, Muscle Invasive Bladder Cancer or Metastatic Muscle Invasive Bladder Cancer.
(FR)
L'invention concerne une composition comprenant des ARN double brin (ARNdb) essentiellement constituée d'un ARNdb comportant deux brins complémentaires, comprenant au moins un bloc ou homopolymère de poly A et le bloc ou homopolymère complémentaire de poly U, chaque bloc comprenant au moins 15, 20, 25 ou 30 A, ou U, chaque brin ayant une longueur déterminée comprise entre 50 et 200 bases, de préférence entre 55 et 200 bases, tous les brins ou sensiblement tous les brins ont la longueur déterminée, et un support, vecteur ou excipient pharmaceutiquement acceptable. La composition peut être utilisée dans le traitement du cancer de la vessie n'infiltrant pas le muscle, du cancer de la vessie infiltrant le muscle ou du cancer métastatique de la vessie infiltrant le muscle.
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