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1. WO2021089609 - MULTISPECIFIC ANTIBODY

Publication Number WO/2021/089609
Publication Date 14.05.2021
International Application No. PCT/EP2020/080941
International Filing Date 04.11.2020
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/32 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
32against translation products from oncogenes
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
C07K 16/2809
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2809against the T-cell receptor (TcR)-CD3 complex
C07K 16/2827
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2827against B7 molecules, e.g. CD80, CD86
C07K 16/2866
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2866against receptors for cytokines, lymphokines, interferons
C07K 16/2878
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2878against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
Applicants
  • NUMAB THERAPEUTICS AG [CH]/[CH]
Inventors
  • URECH, David
  • HESS, Christian
  • SIMONIN, Alexandre
  • WARMUTH, Stefan
Agents
  • WALLINGER RICKER SCHLOTTER TOSTMANN
Priority Data
19206959.904.11.2019EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MULTISPECIFIC ANTIBODY
(FR) ANTICORPS MULTISPÉCIFIQUES
Abstract
(EN)
The present invention relates to a multispecific antibody comprising at least one domain specifically binding to a tumor-associated immune checkpoint antigen with low affinity, and at least one domain specifically binding to a tumor-associated antigen (TAA), and pharmaceutical compositions and methods of use thereof. The present invention further relates to a nucleic acid encoding said multispecific antibody, a vector comprising said nucleic acid, a host cell comprising said nucleic acid or said vector, and a method of producing said multispecific antibody
(FR)
La présente invention concerne un anticorps multispécifique comprenant au moins un domaine se liant de manière spécifique à un antigène de point de contrôle immunitaire associé à une tumeur avec une faible affinité, et au moins un domaine se liant de manière spécifique à un antigène associé à une tumeur (TAA), des compositions pharmaceutiques et leurs procédés d'utilisation. La présente invention concerne en outre un acide nucléique codant pour ledit anticorps multispécifique, un vecteur comprenant ledit acide nucléique, une cellule hôte comprenant ledit acide nucléique ou ledit vecteur, et un procédé de production dudit anticorps multispécifique.
Also published as
Latest bibliographic data on file with the International Bureau