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1. WO2021084411 - SUBSTANTIALLY PURE CLARITHROMYCIN 9-OXIME AND ITS PREPARATION THEREOF

Publication Number WO/2021/084411
Publication Date 06.05.2021
International Application No. PCT/IB2020/060051
International Filing Date 27.10.2020
IPC
A61K 31/7048 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
CPC
A61K 31/7048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin ; digitoxin or digoxin
C07H 17/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
08Hetero rings containing eight or more ring members, e.g. erythromycins
Applicants
  • HIKAL LIMITED [IN]/[IN]
  • GALAPAGOS [BE]/[BE]
Inventors
  • NAMBIAR, Sudhir
  • GANORKAR, Rakesh Ramesh
  • CHAUDHARI, Kiran
  • GOHAR, Anil
  • SINGH, Deeksha
  • CLAERHOUT STIJN POL, Patrick
Agents
  • SHARMA, Sweety
Priority Data
20192104372229.10.2019IN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTANTIALLY PURE CLARITHROMYCIN 9-OXIME AND ITS PREPARATION THEREOF
(FR) CLARITHROMYCINE 9-OXIME SENSIBLEMENT PURE ET SA PRÉPARATION
Abstract
(EN) The present invention relates to substantially pure Clarithromycin 9-oxime more particularly Clarithromycin 9(E)-oxime having purity more than 98% and corresponding (Z)-isomer not more than 1%. The present invention further relates to a process for preparation of Clarithromycin 9(E)-oxime of formula (I), its pharmaceutically acceptable salts and purification.
(FR) La présente invention concerne de la clarithromycine 9-oxime sensiblement pure, plus particulièrement de la clarithromycine 9 (E)-oxime présentant une pureté supérieure à 98% et un isomère (Z) correspondant inférieur ou égal à 1%. La présente invention concerne en outre un procédé de préparation de clarithromycine 9(E)-oxime de formule (I), ses sels pharmaceutiquement acceptables et sa purification.
Latest bibliographic data on file with the International Bureau