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1. WO2021080262 - "INTRAVASCULAR THROMBUS" LYTIC AGENT

Publication Number WO/2021/080262
Publication Date 29.04.2021
International Application No. PCT/KR2020/014217
International Filing Date 19.10.2020
IPC
C12N 9/50 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50Proteinases
A61P 7/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/482
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
482Serine endopeptidases (3.4.21)
A61K 38/484
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
482Serine endopeptidases (3.4.21)
484Plasmin (3.4.21.7)
A61P 7/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
C12N 9/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
14Hydrolases (3)
48acting on peptide bonds (3.4)
50Proteinases ; , e.g. Endopeptidases (3.4.21-3.4.25)
C12Y 304/21
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
304Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
21Serine endopeptidases (3.4.21)
Applicants
  • 주식회사 지니스 JINIS CO.,LTD. [KR]/[KR]
Inventors
  • 홍성출 HONG, Seong Tshool
  • 김현진 KIM, Hyeon Jin
  • 하산엠디메헤디 HASSAN, Mdmehedi
Agents
  • 특허법인(유한) 해담 HAEDAM IP GROUP
Priority Data
10-2019-013158522.10.2019KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) "INTRAVASCULAR THROMBUS" LYTIC AGENT
(FR) AGENT LYTIQUE POUR « THROMBUS INTRAVASCULAIRE »
(KO) '혈관내 혈전' 용해제
Abstract
(EN) The present invention relates to an "intravascular thrombus" lytic agent and, more specifically, to a polypeptide, a gene, and a pharmaceutical composition comprising same, wherein the polypeptide is composed of a thrombo-recognition domain and a thrombolytic domain for "intravascular thrombus" and functions to lyse an "intravascular thrombus". The polypeptide recognizing and lysing an "intravascular thrombus" of the present invention is composed of a thrombolytic domain including the amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 2 and a thrombo-recognition domain including the amino acid sequence represented by SEQ ID NO: 3 or SEQ ID NO: 4. The polypeptide that recognizes and lyses an "intravascular thrombus" according to the present invention lyses intravascular thrombi in mammals without significant hemorrhage side effects and has a prophylactic and therapeutic effect on thrombosis, thus finding wide applications as a prophylactic or therapeutic agent for thrombosis and related diseases.
(FR) La présente invention concerne un agent lytique pour un « thrombus intravasculaire » et, plus précisément, un polypeptide, un gène, et une composition pharmaceutique le comprenant, le polypeptide étant composé d'un domaine de reconnaissance de thrombose et d'un domaine thrombolytique pour le « thrombus intravasculaire » et agissant de façon à lyser un « thrombus intravasculaire ». Le polypeptide reconnaissant et lysant un « thrombus intravasculaire » de la présente invention est composé d'un domaine thrombolytique comprenant la séquence d'acides aminés représentée par SEQ ID No : 1 ou SEQ ID No : 2, et un domaine de reconnaissance de thrombose comprenant la séquence d'acides aminés représentée par SEQ ID No : 3 ou SEQ ID No : 4. Le polypeptide qui reconnaît et lyse un « thrombus intravasculaire » selon la présente invention lyse des thrombus intravasculaires chez des mammifères sans effets secondaires hémorragiques graves, et présente un effet prophylactique et thérapeutique sur la thrombose, ce qui lui permet de pouvoir être largement appliqué en tant qu'agent prophylactique ou thérapeutique contre la thrombose et les maladies associées.
(KO) 본 발명은 '혈관내 혈전' 용해제에 관한 것으로서, 더욱 상세하게는 '혈관내 혈전'에 대한 혈전인지 도메인(thrombo-recognition domain)과 혈전용해 도메인(thrombolytic domain)으로 구성되어, '혈관내 혈전'을 용해하는 기능의 폴리펩티드, 유전자 및 이를 함유하는 약학 조성물에 관한 것이다. 본 발명의 '혈관내 혈전'을 인지하여 혈전을 용해하는 폴리펩티드는 서열번호 1 또는 서열번호 2로 기재되는 아미노산 서열을 포함하는 혈전용해 도메인 및 서열번호 3 또는 서열번호 4로 기재되는 아미노산 서열을 포함하는 혈전인지 도메인으로 구성되는 것을 특징으로 한다. 본 발명에 따른, '혈관내 혈전'을 인지하여 혈전을 용해하는 폴리펩티드는 심각한 출혈 부작용이 없이 포유동물의 혈액 내 혈전을 용해시켜 혈전증에 대한 예방 및 치료 효능을 가지므로, 혈전증 및 관련 질환의 예방 또는 치료제로 널리 이용될 수 있다.
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