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1. WO2021072055 - COMPOSITIONS AND METHODS FOR PREVENTING, REDUCING AND REVERSING OPIOID-INDUCED RESPIRATORY DEPRESSION

Publication Number WO/2021/072055
Publication Date 15.04.2021
International Application No. PCT/US2020/054759
International Filing Date 08.10.2020
IPC
A61K 31/137 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
135having aromatic rings, e.g. methadone
137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A61P 25/08 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
08Antiepileptics; Anticonvulsants
CPC
A61K 31/4468
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
4468having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
A61K 38/095
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
095Oxytocins; Vasopressins; Related peptides
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 25/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
08Antiepileptics; Anticonvulsants
Applicants
  • BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US]/[US]
Inventors
  • TONEY, Glenn, M.
  • BRACKLEY, Allison, D.
Agents
  • KLIEM, Michele A.
  • KATZ, Mitchell, A.
  • MEADOWS, Brian, C.
  • MARTY, Scott D.
  • SHORTELL, D., Brian
Priority Data
62/914,02511.10.2019US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR PREVENTING, REDUCING AND REVERSING OPIOID-INDUCED RESPIRATORY DEPRESSION
(FR) COMPOSITIONS ET PROCÉDÉS DE PRÉVENTION, DE RÉDUCTION ET D'INVERSION DE LA DÉPRESSION RESPIRATOIRE INDUITE PAR DES OPIOÏDES
Abstract
(EN) The disclosure relates to compositions and methods of preventing, reducing, reversing or treating a subject suffering from opioid toxicity, overdose or opioid-induced respiratory depression or a subject at risk for developing opioid-induced respiratory depression. The method comprises administering to a patient in need of treatment an effective amount of oxytocin or an analog thereof.
(FR) L'invention concerne des compositions et des procédés de prévention, de réduction, d'inversion ou de traitement d'un sujet atteint d'une toxicité opioïde, d'une surdose ou d'une dépression respiratoire induite par les opioïdes ou d'un sujet présentant un risque de développer une dépression respiratoire induite par les opioïdes. Le procédé comprend l'administration à un patient ayant besoin d'un traitement d'une quantité efficace d'oxytocine ou d'un analogue de celle-ci.
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