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1. WO2021067946 - BIOMARKER-BASED TREATMENT OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS AND DIABETIC KIDNEY DISEASE

Publication Number WO/2021/067946
Publication Date 08.04.2021
International Application No. PCT/US2020/054282
International Filing Date 05.10.2020
IPC
A61K 31/4164 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
C07D 235/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
235Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02condensed with carbocyclic rings or ring systems
04Benzimidazoles; Hydrogenated benzimidazoles
A61P 13/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
Applicants
  • GOLDFINCH BIO, INC. [US]/[US]
Inventors
  • REILLY, John Francis
  • DAGON, Yossi
  • RAGHU, Hari
  • COEFFET-LE GAL, Marie-Francoise Yveline
  • DANIELS, Matthew H.
  • YU, Maolin
  • LEDEBOER, Mark W.
  • HARMANGE, Jean-Christophe P.
  • MUNDEL, Peter H.
Agents
  • GORDON, Dana M.
  • CHATTERLEY, Alexander, J.
  • AKHIEZER, Alexander
  • CAI, Mi
  • ABELLEIRA, Susan, M.
  • CHOI, Philip, S.
Priority Data
62/910,75804.10.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BIOMARKER-BASED TREATMENT OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS AND DIABETIC KIDNEY DISEASE
(FR) TRAITEMENT À BASE DE BIOMARQUEURS DE LA GLOMÉRULOSCLÉROSE SEGMENTAIRE FOCALE ET DE LA NÉPHROPATHIE DIABÉTIQUE
Abstract
(EN)
Disclosed are compounds having structural formulas (I)-(XI), and related pharmaceutical compositions. Also disclosed are methods of selecting and treating human subjects suffering from a kidney disease, using the compounds of formulas (I)-(XI), and methods of determining the efficacy of TRPC5 inhibitor therapies using the same.
(FR)
L'invention concerne des composés ayant des formules structurales (I)-(XI), et des compositions pharmaceutiques associées. L'invention concerne également des procédés de sélection et de traitement de sujets humains atteints d'une maladie rénale, à l'aide des composés de formules (I)-(XI), et des procédés de détermination de l'efficacité de thérapies à base d'inhibiteurs de TRPC5 l'utilisant.
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