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1. WO2021067785 - STAPHYLOCOCCUS PEPTIDES AND METHODS OF USE

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Publication Number WO/2021/067785
Publication Date 08.04.2021
International Application No. PCT/US2020/054047
International Filing Date 02.10.2020
IPC
C07K 14/31 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
305from Micrococcaceae (F)
31from Staphylococcus (G)
A61K 39/085 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
085Staphylococcus
Applicants
  • JANSSEN VACCINES & PREVENTION B.V [NL]/[NL]
  • THE UNIVERSITY OF CHICAGO [US]/[US]
Inventors
  • POOLMAN, Jan Theunis
  • SCHNEEWIND, Olaf
  • MISSIAKAS, Dominique
  • SUN, Yan
  • KIM, Hwan Keun
  • SHI, Miaomiao
  • CHEN, Xinhai
  • FERNANDEZ, Jeffrey A.
Agents
  • BARANIAK, Andrew, P.
  • BOSE, Siddharth
  • COLE, Troy, J.
  • BERG, Amy
  • BANTA, Holiday, W.
Priority Data
62/909,45802.10.2019US
62/909,47302.10.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) STAPHYLOCOCCUS PEPTIDES AND METHODS OF USE
(FR) PEPTIDES DE STAPHYLOCOCCUS ET PROCÉDÉS D'UTILISATION
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Abstract
(EN)
Provided herein are immunogenic compositions comprising a Staphylococcus aureus protein A (SpA) variant and a mutant staphylococcal leukocidin subunit polypeptide comprising a LukA polypeptide, a LukB polypeptide, and/or a LukAB dimer polypeptide, wherein the LukA polypeptide, the LukB polypeptide, and/or the LukAB dimer polypeptide have one or more amino acid substitutions, deletions, or a combination thereof.
(FR)
L'invention concerne des compositions immunogènes comprenant un variant de protéine A de Staphylococcus aureus (SpA) et un polypeptide de sous-unité de leucocidine staphylococcique mutante comprenant un polypeptide LukA, un polypeptide LukB, et/ou un polypeptide dimère LukAB, le polypeptide LukA, le polypeptide LukB, et/ou le polypeptide dimère LukAB ayant une ou plusieurs substitutions ou délétions d'acides aminés ou une combinaison de celles-ci.
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