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1. WO2021067785 - STAPHYLOCOCCUS PEPTIDES AND METHODS OF USE

Publication Number WO/2021/067785
Publication Date 08.04.2021
International Application No. PCT/US2020/054047
International Filing Date 02.10.2020
IPC
C07K 14/31 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
305from Micrococcaceae (F)
31from Staphylococcus (G)
A61K 39/085 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
085Staphylococcus
Applicants
  • JANSSEN VACCINES & PREVENTION B.V [NL]/[NL]
  • THE UNIVERSITY OF CHICAGO [US]/[US]
Inventors
  • POOLMAN, Jan Theunis
  • SCHNEEWIND, Olaf
  • MISSIAKAS, Dominique
  • SUN, Yan
  • KIM, Hwan Keun
  • SHI, Miaomiao
  • CHEN, Xinhai
  • FERNANDEZ, Jeffrey A.
Agents
  • BARANIAK, Andrew, P.
  • BOSE, Siddharth
  • COLE, Troy, J.
  • BERG, Amy
  • BANTA, Holiday, W.
Priority Data
62/909,45802.10.2019US
62/909,47302.10.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) STAPHYLOCOCCUS PEPTIDES AND METHODS OF USE
(FR) PEPTIDES DE STAPHYLOCOCCUS ET PROCÉDÉS D'UTILISATION
Abstract
(EN)
Provided herein are immunogenic compositions comprising a Staphylococcus aureus protein A (SpA) variant and a mutant staphylococcal leukocidin subunit polypeptide comprising a LukA polypeptide, a LukB polypeptide, and/or a LukAB dimer polypeptide, wherein the LukA polypeptide, the LukB polypeptide, and/or the LukAB dimer polypeptide have one or more amino acid substitutions, deletions, or a combination thereof.
(FR)
L'invention concerne des compositions immunogènes comprenant un variant de protéine A de Staphylococcus aureus (SpA) et un polypeptide de sous-unité de leucocidine staphylococcique mutante comprenant un polypeptide LukA, un polypeptide LukB, et/ou un polypeptide dimère LukAB, le polypeptide LukA, le polypeptide LukB, et/ou le polypeptide dimère LukAB ayant une ou plusieurs substitutions ou délétions d'acides aminés ou une combinaison de celles-ci.
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