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1. WO2021066608 - COMPOUND FOR INDUCING EXPRESSION OF ANTI-AGING GENE KLOTHO AND USE THEREOF

Publication Number WO/2021/066608
Publication Date 08.04.2021
International Application No. PCT/KR2020/013480
International Filing Date 05.10.2020
IPC
C07D 263/56 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
52condensed with carbocyclic rings or ring systems
54Benzoxazoles; Hydrogenated benzoxazoles
56with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
C07D 263/58 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
52condensed with carbocyclic rings or ring systems
54Benzoxazoles; Hydrogenated benzoxazoles
58with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
A61K 31/421 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42Oxazoles
4211,3-Oxazoles, e.g. pemoline, trimethadione
A61P 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 13/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61K 8/49 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
Applicants
  • 주식회사 클로소사이언스 KLOTHO SCIENCES [KR]/[KR]
Inventors
  • 정동주 JUNG, Dong Ju
Agents
  • 파도특허법인(유한) PADO IP PLLC
Priority Data
10-2019-012230502.10.2019KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOUND FOR INDUCING EXPRESSION OF ANTI-AGING GENE KLOTHO AND USE THEREOF
(FR) COMPOSÉ DESTINÉ À INDUIRE L'EXPRESSION D'UN GÈNE KLOTHO ANTI-ÂGE ET SON UTILISATION
(KO) 항노화 유전자 KLOTHO의 발현을 유도하는 화합물 및 이의 용도
Abstract
(EN)
The present invention relates to a compound for inducing the expression of the anti-aging gene klotho and a production method therefor. The compound represented by chemical formula 1, according to the present invention, has an excellent effect of increasing the expression level of the klotho gene which is a gene associated with aging, and thus may be useful for a pharmaceutical composition, cosmetic composition or food composition for preventing skin aging, inhibiting cellular senescence or preventing, treating, alleviating vascular aging-induced diseases or kidney disease.
(FR)
La présente invention concerne un composé destiné à induire l'expression du gène klotho anti-âge et un procédé de production associé. Le composé représenté par la formule chimique 1, selon la présente invention, a pour effet de renforcer, de façon remarquable, le niveau d'expression du gène klotho qui est un gène associé au vieillissement, et peut ainsi être utile pour une composition pharmaceutique, une composition cosmétique ou une composition alimentaire destinée à prévenir le vieillissement cutané, inhiber la sénescence cellulaire ou prévenir, traiter, soulager des maladies vasculaires induites par le vieillissement ou des maladies rénales.
(KO)
본 발명은 항노화 유전자 klotho의 발현을 유도하는 화합물 및 이의 제조방법에 관한 것으로, 본 발명에 따른 화학식 1로 표시되는 화합물은 노화와 관련된 유전자인 Klotho 유전자의 발현량을 향상시키는 효과가 우수하고, 이에 따라 피부 노화 방지, 세포 노화 억제 또는 혈관 노화로 인해 유발되는 질환 또는 신장질환 관련 의 예방, 치료, 개선용 약학 조성물, 화장료 조성물 또는 식품 조성물로 유용할 수 있다.
Also published as
Latest bibliographic data on file with the International Bureau