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1. WO2021066134 - MONOCLONAL ANTIBODY OR ANTIBODY FRAGMENT AGAINST CANINE CD20

Publication Number WO/2021/066134
Publication Date 08.04.2021
International Application No. PCT/JP2020/037514
International Filing Date 02.10.2020
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C12N 15/13 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
CPC
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
G01N 33/53
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
Applicants
  • 日本全薬工業株式会社 NIPPON ZENYAKU KOGYO CO., LTD. [JP]/[JP]
Inventors
  • 水野 拓也 MIZUNO Takuya
Agents
  • 特許業務法人 もえぎ特許事務所 MOEGI PATENT OFFICE
Priority Data
2019-18307903.10.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) MONOCLONAL ANTIBODY OR ANTIBODY FRAGMENT AGAINST CANINE CD20
(FR) ANTICORPS MONOCLONAL OU FRAGMENT D'ANTICORPS CONTRE CD20 CANIN
(JA) イヌCD20に対するモノクローナル抗体又は抗体フラグメント
Abstract
(EN)
The present invention addresses the problem of providing a monoclonal antibody against canine CD20, the antibody being superior in effect to conventional antibodies. Provided is a monoclonal antibody or an antibody fragment against canine CD20, the monoclonal antibody comprising: a heavy chain variable region that comprises the amino acid sequence represented by SEQ ID NO:1 or an amino acid sequence with deletion, substitution or addition of one to several amino acids in the amino acid sequence represented by SEQ ID NO:1; a light chain variable region that comprises the amino acid sequence represented by SEQ ID NO:2 or an amino acid sequence with deletion, substitution or addition of one to several amino acids in the amino acid sequence represented by SEQ ID NO:2; and a light chain constant region that comprises the amino acid sequence represented by SEQ ID NO:3 or an amino acid sequence with deletion, substitution or addition of one to several amino acids in the amino acid sequence represented by SEQ ID NO:3.
(FR)
La présente invention aborde le problème de la fourniture d'un anticorps monoclonal contre le CD20 canin, l'anticorps étant supérieur en effet aux anticorps classiques. L'invention concerne un anticorps monoclonal ou un fragment d'anticorps contre le CD20 canin, l'anticorps monoclonal comprenant : une région variable de chaîne lourde qui comprend la séquence d'acides aminés représentée par SEQ ID NO : 1 ou une séquence d'acides aminés avec délétion, substitution ou addition d'un à plusieurs acides aminés dans la séquence d'acides aminés représentée par SEQ ID NO : 1 ; une région variable de chaîne légère qui comprend la séquence d'acides aminés représentée par SEQ ID NO : 2 ou une séquence d'acides aminés avec délétion, substitution ou addition d'un à plusieurs acides aminés dans la séquence d'acides aminés représentée par SEQ ID NO : 2 ; et une région constante de chaîne légère qui comprend la séquence d'acides aminés représentée par SEQ ID NO : 3 ou une séquence d'acides aminés avec délétion, substitution ou addition d'un à plusieurs acides aminés dans la séquence d'acides aminés représentée par SEQ ID NO : 3.
(JA)
既存の抗体と比べて、より効果が優れたイヌCD20に対するモノクローナル抗体の提供を課題とする。 配列番号1に記載のアミノ酸配列或いは配列番号1のアミノ酸配列において1若しくは数個のアミノ酸が欠失、置換若しくは付加されたアミノ酸配列からなる重鎖可変領域、及び、配列番号2に記載のアミノ酸配列或いは配列番号2のアミノ酸配列において1若しくは数個のアミノ酸が欠失、置換若しくは付加されたアミノ酸配列からなる軽鎖可変領域を有し、かつ、配列番号3に記載のアミノ酸配列又は配列番号3に記載のアミノ酸配列において1若しくは数個のアミノ酸が欠失、置換若しくは付加されたアミノ酸配列からなる軽鎖定常領域を有するイヌCD20に対するモノクローナル抗体又は抗体フラグメントを提供する。
Also published as
Latest bibliographic data on file with the International Bureau