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1. WO2021062332 - COMBINATION OF INHIBITORS OF IL4 SIGNALING AND IMMUNE CHECKPOINTS FOR TREATING CANCER

Publication Number WO/2021/062332
Publication Date 01.04.2021
International Application No. PCT/US2020/052961
International Filing Date 26.09.2020
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 16/24 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 2039/507
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
507Comprising a combination of two or more separate antibodies
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 16/247
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
244Interleukins [IL]
247IL-4
C07K 16/2827
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2827against B7 molecules, e.g. CD80, CD86
C07K 16/2878
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2878against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
Applicants
  • ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI [US]/[US]
Inventors
  • MERAD, Miriam
Agents
  • MCCOOL, Gabriel J.
  • BAKER, C. Hunter
  • ATTISHA, Michael J.
  • ALAM, Saad
  • AMUNDSEN, Eric L.
Priority Data
62/907,16127.09.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMBINATION OF INHIBITORS OF IL4 SIGNALING AND IMMUNE CHECKPOINTS FOR TREATING CANCER
(FR) ASSOCIATION D'INHIBITEURS DE LA SIGNALISATION DE L'IL4 ET DE POINTS DE CONTRÔLE IMMUNITAIRES POUR LE TRAITEMENT DU CANCER
Abstract
(EN)
The present disclosure provides for cancer therapies that comprise administering inhibitors of IL4 signaling to a subject in need thereof, particularly in combination with an immune checkpoint inhibitor.
(FR)
La présente invention concerne des thérapies anticancéreuses qui consistent à administrer à un sujet qui en a besoin des inhibiteurs de la signalisation de l'IL4, en particulier en association avec un inhibiteur de points de contrôle immunitaires.
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