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1. WO2021062323 - ANTIBODIES SPECIFIC TO GLYCOSYLATED CTLA-4 AND METHODS OF USE THEREOF

Publication Number WO/2021/062323
Publication Date 01.04.2021
International Application No. PCT/US2020/052949
International Filing Date 25.09.2020
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
C07K 16/2818
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2818against CD28 or CD152
C07K 2317/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
24containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
C07K 2317/41
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
40characterized by post-translational modification
41Glycosylation, sialylation, or fucosylation
C07K 2317/76
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
C07K 2317/92
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
90characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applicants
  • STCUBE & CO. [KR]/[KR]
Inventors
  • YOO, Stephen, S.
Agents
  • BRIVANLOU, Margaret
  • KATZ, Mitchell, A.
  • MEADOWS, Brian, C.
  • MARTY, Scott, D.
  • SHORTELL, D., Brian
Priority Data
62/906,50026.09.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTIBODIES SPECIFIC TO GLYCOSYLATED CTLA-4 AND METHODS OF USE THEREOF
(FR) ANTICORPS SPÉCIFIQUES DIRIGÉS CONTRE CTLA-4 GLYCOSYLÉE ET LEURS PROCÉDÉS D'UTILISATION
Abstract
(EN)
Antibodies that selectively bind to glycosylated CTLA-4 relative to unglycosylated CTLA-4 are provided. In some aspects, CTLA-4 polypeptides comprising glycosylated amino acid positions are also provided. Methods for making and using such antibodies and polypeptides (e.g., for the treatment of cancer) are also provided.
(FR)
L'invention concerne des anticorps qui se lient de manière spécifique à CTLA-4 glycosylée par rapport à une CTLA-4 non glycosylée. Dans certains aspects, l'invention concerne également des polypeptides de CTLA-4 comprenant des positions d'acides aminés glycosylés. L'invention concerne en outre des procédés de production et d'utilisation de tels anticorps et polypeptides (par exemple, pour le traitement du cancer).
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