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1. WO2021062041 - NOVEL ANTIBODIES FOR DETECTING GASTRIC CANCER

Publication Number WO/2021/062041
Publication Date 01.04.2021
International Application No. PCT/US2020/052561
International Filing Date 24.09.2020
IPC
G01N 33/53 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
G01N 33/543 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
C07K 16/121
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
12against material from bacteria
1203from Gram-negative bacteria
121from Helicobacter (Campylobacter) (G)
G01N 2333/205
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
195from bacteria
205from Campylobacter (G)
G01N 2469/20
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2469Immunoassays for the detection of microorganisms
20Detection of antibodies in sample from host which are directed against antigens from microorganisms
G01N 2800/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
50Determining the risk of developing a disease
G01N 33/543
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
G01N 33/56922
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
56911Bacteria
56922Campylobacter
Applicants
  • LABAER, Joshua [US]/[US]
  • QIU, Ji [CN]/[US]
  • SONG, Lusheng [US]/[US]
  • CHUNG, Yunro [KR]/[US]
Inventors
  • LABAER, Joshua
  • QIU, Ji
  • SONG, Lusheng
  • CHUNG, Yunro
Agents
  • LEWIS, Jessica L.
  • BABEL, Angeline R.
  • VANHEYNINGEN, Tambryn
Priority Data
62/904,83324.09.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL ANTIBODIES FOR DETECTING GASTRIC CANCER
(FR) NOUVEAUX ANTICORPS POUR LA DÉTECTION DU CANCER GASTRIQUE
Abstract
(EN)
Provided herein are methods, compositions, kits, and systems for diagnosing, predicting, and treating gastric cancer for a subject based on the presence and level of antibodies against particular H. pylori proteins in a biological sample obtained from the subject. In particular, provided herein are methods for identifying a subject having increased risk of developing gastric cancer, methods for detecting gastric cancer in a subject, methods for determining an H. pylori antibody signature comprising antibodies, contained in a biological sample from a subject, that specifically bind to immobilized H. pylori antigens, and kits comprising components and instructions for performing the methods of this disclosure.
(FR)
La présente invention concerne des procédés, compositions, kits, et des systèmes pour le diagnostic, la prévision et le traitement du cancer gastrique pour un sujet sur la base de la présence et du niveau d'anticorps contre des protéines de H. pylori particulières dans un échantillon biologique obtenu auprès du sujet. En particulier, la présente invention concerne des procédés d'identification d'un sujet présentant un risque accru de développer un cancer gastrique, des procédés de détection du cancer gastrique chez un sujet, des procédés de détermination d'une signature d'anticorps de H. pylori comprenant des anticorps, contenus dans un échantillon biologique provenant d'un sujet, qui se lient spécifiquement à des antigènes de H. pylori immobilisés, et des kits comprenant des composants et des instructions pour mettre en oeuvre les procédés de l'invention.
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