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1. WO2021061929 - BICYCLIC CARBOXYLATES AS MODULATORS OF TRANSPORTERS AND USES THEREOF

Publication Number WO/2021/061929
Publication Date 01.04.2021
International Application No. PCT/US2020/052413
International Filing Date 24.09.2020
IPC
A61K 31/429 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425Thiazoles
429condensed with heterocyclic ring systems
C07D 493/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 495/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61K 31/429
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
425Thiazoles
429condensed with heterocyclic ring systems
C07D 495/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • NIROGY THERAPEUTICS, INC. [US]/[US]
Inventors
  • SANDANAYAKA, Vincent
  • GORECZNY, Gregory
Agents
  • DONG, Yaohua
  • KEZER, William B.
  • DOLAN, Gregory F.
Priority Data
62/905,60625.09.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BICYCLIC CARBOXYLATES AS MODULATORS OF TRANSPORTERS AND USES THEREOF
(FR) CARBOXYLATES BICYCLIQUES UTILISÉS EN TANT QUE MODULATEURS DE TRANSPORTEURS ET LEURS UTILISATIONS
Abstract
(EN)
The present invention generally relates to the field of transporter modulators, e.g., monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.
(FR)
La présente invention concerne d'une manière générale le domaine des modulateurs de transporteurs, par exemple, des inhibiteurs de transporteurs de monocarboxylate, et plus particulièrement de nouveaux composés de carboxylate d'énone bicyclique, la synthèse et l'utilisation de ces composés et leurs compositions pharmaceutiques, par exemple dans le traitement, la modulation et/ou la prévention de conditions physiologiques associées à une activité de transporteur de monocarboxylate telle que dans le traitement du cancer et d'autres troubles néoplasiques, du rejet de greffe de tissu et d'organe.
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