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1. WO2021061859 - NOVEL RECEPTORS FOR LIGAND-DEPENDENT TRANSCRIPTIONAL REGULATION

Publication Number WO/2021/061859
Publication Date 01.04.2021
International Application No. PCT/US2020/052324
International Filing Date 23.09.2020
IPC
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
C07K 16/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
CPC
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US]
Inventors
  • ROYBAL, Kole, T.
  • LIU, Raymond
  • ZHU, Iowis
Agents
  • XU, Lei
  • ADAMS, Lisa
  • AMENDT, Kevin, C.
  • ALLISON, William, F.
  • AZRIN, Linda, B.
Priority Data
62/905,24824.09.2019US
62/935,02413.11.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL RECEPTORS FOR LIGAND-DEPENDENT TRANSCRIPTIONAL REGULATION
(FR) NOUVEAUX RÉCEPTEURS POUR LA RÉGULATION TRANSCRIPTIONNELLE DÉPENDANT D'UN LIGAND
Abstract
(EN)
The present disclosure generally relates to, among other things, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. Particularly, the new receptors, even though derived from Notch, do not require the Notch negative regulatory regions previously believed to be essential for the functioning of the receptors. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions or diseases, such as cancers.
(FR)
La présente invention concerne de manière générale, entre autres, une nouvelle classe de récepteurs modifiés pour moduler la régulation transcriptionnelle d'une manière dépendante d'un ligand. En particulier, les nouveaux récepteurs, même s'ils sont dérivés de Notch, ne nécessitent pas les régions régulatrices négatives Notch précédemment considérées comme essentielles pour le fonctionnement des récepteurs. L'invention concerne également des compositions et des procédés utiles pour produire de tels récepteurs, des acides nucléiques codant pour ceux-ci, des cellules hôtes génétiquement modifiées avec les acides nucléiques, ainsi que des procédés de modulation d'une activité d'une cellule et/ou pour le traitement de divers états de santé ou maladies, comme des cancers.
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