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1. WO2021061790 - SYSTEMS AND METHODS FOR CHROMATOGRAPHY USE AND REGENERATION

Publication Number WO/2021/061790
Publication Date 01.04.2021
International Application No. PCT/US2020/052243
International Filing Date 23.09.2020
IPC
G01N 30/40 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
26Conditioning of the fluid carrier; Flow patterns
38Flow patterns
40using back flushing
G01N 30/50 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
50Conditioning of the sorbent material or stationary liquid
CPC
G01N 30/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography ; or field flow fractionation;
02Column chromatography
50Conditioning of the sorbent material or stationary liquid
G01N 30/88
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography ; or field flow fractionation;
02Column chromatography
88Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
G01N 30/96
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography ; or field flow fractionation;
96using ion-exchange
Applicants
  • REGENERON PHARMACEUTICALS, INC. [US]/[US]
Inventors
  • STAIRS, Robert
  • REILLY, James
  • MATTILA, John
  • WADSWORTH, Samantha
Agents
  • PORTIS, Jason B.
Priority Data
62/905,03324.09.2019US
62/958,89909.01.2020US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SYSTEMS AND METHODS FOR CHROMATOGRAPHY USE AND REGENERATION
(FR) SYSTÈMES ET PROCÉDÉS D'UTILISATION ET DE RÉGÉNÉRATION DE CHROMATOGRAPHIE
Abstract
(EN)
Aspects of the present disclosure relate to a method of regenerating a hydrophobic interaction chromatography column to which a load mass has been applied, the method comprising passing one or more column volumes of an alkaline solution through hydrophobic interaction media within the column, wherein the alkaline solution exhibits a pH of between about 10 and about 14, and a conductivity of between 0.5 mS/cm and about 10 mS/cm, wherein material bound to the hydrophobic interaction media is removed. In some cases, the alkaline solution may include sodium hydroxide at a concentration of between, e.g., about 0.1 mM and 10 mM.
(FR)
Des aspects de la présente invention concernent un procédé de régénération d'une colonne de chromatographie d'interaction hydrophobe sur laquelle une masse de charge a été appliquée, le procédé consistant à faire passer un ou plusieurs volumes de colonne d'une solution alcaline à travers le milieu d'interaction hydrophobes à l'intérieur de la colonne, la solution alcaline présentant un pH compris entre environ 10 et environ 14, et une conductivité comprise entre 0,5 mS/cm et environ 10 mS/cm, le matériau lié au milieu d'interaction hydrophobe étant éliminé. Dans certains cas, la solution alcaline peut comprendre de l'hydroxyde de sodium à une concentration comprise, par exemple, entre environ 0,1 mM et 10 mM
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