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1. WO2021061658 - PRODUCT QUALITY ATTRIBUTE MEASUREMENT

Publication Number WO/2021/061658
Publication Date 01.04.2021
International Application No. PCT/US2020/052019
International Filing Date 22.09.2020
IPC
G01N 30/42 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
26Conditioning of the fluid carrier; Flow patterns
38Flow patterns
42using counter-current
B01D 15/18 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08Selective adsorption, e.g. chromatography
10characterised by constructional or operational features
18relating to flow patterns
G01N 30/88 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
88Integrated analysis systems specially adapted therefor, not covered by a single one of groups G01N30/04-G01N30/86146
G01N 30/46 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
26Conditioning of the fluid carrier; Flow patterns
38Flow patterns
46using more than one column
CPC
B01D 15/1807
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
10characterised by constructional or operational features
18relating to flow patterns
1807using counter-currents, e.g. fluidised beds
B01D 15/1864
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
10characterised by constructional or operational features
18relating to flow patterns
1864using two or more columns
C07K 16/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
22against growth factors ; ; against growth regulators
C12M 33/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
33Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
C12M 41/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
41Means for regulation, monitoring, measurement or control, e.g. flow regulation
C12M 41/30
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
41Means for regulation, monitoring, measurement or control, e.g. flow regulation
30of concentration
Applicants
  • GENZYME CORPORATION [US]/[US]
Inventors
  • HINCAPIE, Marina
  • BERGER, Victoria
Agents
  • WHYTE, Jasmine M.
  • REITER, Tiffany
Priority Data
62/904,68223.09.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PRODUCT QUALITY ATTRIBUTE MEASUREMENT
(FR) MESURE D'ATTRIBUT DE QUALITÉ DE PRODUIT
Abstract
(EN)
Systems for measuring a product quality attribute of an analyte of a biological sample include a first flow control device, a sample purification device, a second flow control device in fluid communication with first and second sample analyzers, where the first sample analyzer includes a first chromatography column, and a control unit configured so that during operation of the system, the control unit adjusts a configuration of the second flow control device to direct a portion of the biological sample to one of the first and second sample analyzers, and determines a product quality attribute of an analyte of the biological sample based on an analysis of the portion of the biological sample by the one of the first and second sample analyzers.
(FR)
L'invention concerne des systèmes de mesure d'un attribut de qualité de produit d'un analyte d'un échantillon biologique comprenant un premier dispositif de régulation de débit, un dispositif de purification d'échantillon, un second dispositif de commande d'écoulement en communication fluidique avec des premier et second analyseurs d'échantillon, le premier analyseur d'échantillon comprenant une première colonne chromatographique, et une unité de commande configurée de telle sorte que, pendant le fonctionnement du système, l'unité de commande règle une configuration du second dispositif de commande d'écoulement pour diriger une partie de l'échantillon biologique vers l'un des premier et second analyseurs d'échantillon, et détermine un attribut de qualité de produit d'un analyte de l'échantillon biologique sur la base d'une analyse de la partie de l'échantillon biologique par l'un des premier et second analyseurs d'échantillon.
Also published as
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