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1. WO2021058969 - TRIPHENYLENE DERIVATIVES FOR USE IN IMAGING BIOLOGICAL TISSUE OR FLUID

Publication Number WO/2021/058969
Publication Date 01.04.2021
International Application No. PCT/GB2020/052324
International Filing Date 24.09.2020
IPC
A61K 49/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
C07D 277/60 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
60condensed with carbocyclic rings or ring systems
CPC
A61K 49/0021
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
0019characterised by the fluorescent group
0021the fluorescent group being a small organic molecule
A61K 49/006
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
006Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
C07D 263/52
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
52condensed with carbocyclic rings or ring systems
C07D 277/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
60condensed with carbocyclic rings or ring-systems
C07D 293/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
293Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
10condensed with carbocyclic rings or ring systems
12Selenazoles; Hydrogenated selenazoles
C07D 413/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
Applicants
  • CHROMATWIST LIMITED [GB]/[GB]
Inventors
  • PREECE, Jon
  • ROBINSON, Alex
  • JONES, Owen
  • BUTLIN, Michael
  • IQBAL, Parvez
  • SUND, Sareena
Agents
  • HGF LTD
Priority Data
1913756.124.09.2019GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TRIPHENYLENE DERIVATIVES FOR USE IN IMAGING BIOLOGICAL TISSUE OR FLUID
(FR) DÉRIVÉS DE TRIPHÉNYLÈNE POUR UTILISATION DANS L'IMAGERIE DE TISSU OU DE FLUIDE BIOLOGIQUE
Abstract
(EN)
A composition for imaging a biological tissue or fluid comprising a compound of formula (A) and a biologically acceptable diluent or carrier, (A) wherein X represents one of a nitrogen atom, an oxygen atom, a sulphur atom, a phosphorus atom, or a selenium atom; R represents an aromatic group and/or an aliphatic group; p is an integer of 1 to 2; q and s are independently integers of 1, 2, 3, or 4; Y1, Y2, and Y3 independently represent a hydrogen atom, a deuterium atom, a fluorine atom, a chlorine atom, a bromine atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a polyglycol group, an oxygen atom, a nitrogen atom, a cyano group, a nitro group; and/or wherein two or more of Y1, Y2, and Y3 may combine together to form a condensed ring.
(FR)
L'invention concerne une composition d'imagerie d'un tissu ou d'un fluide biologique comprenant un composé de formule (A) et un diluant ou un vecteur biologiquement acceptable, (A) X représentant un atome d'azote, un atome d'oxygène, un atome de soufre, un atome de phosphore ou un atome de sélénium ; R représentant un groupe aromatique et/ou un groupe aliphatique ; p étant un nombre entier égal à 1 ou 2 ; q et s étant indépendamment un nombre entier égal à 1, 2, 3 ou 4 ; Y1, Y2 et Y3 représentant indépendamment un atome d'hydrogène, un atome de deutérium, un atome de fluor, un atome de chlore, un atome de brome, un groupe alkyle substitué ou non substitué, un groupe aryle substitué ou non substitué, un groupe polyglycol, un atome d'oxygène, un atome d'azote, un groupe cyano, un groupe nitro ; et/ou au moins deux éléments parmi Y1, Y2 et Y3 peuvent se combiner pour former un cycle condensé.
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