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1. WO2021058804 - BINDING MODULES COMPRISING MODIFIED EHD2 DOMAINS

Publication Number WO/2021/058804
Publication Date 01.04.2021
International Application No. PCT/EP2020/077008
International Filing Date 25.09.2020
IPC
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/32 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
32against translation products from oncogenes
C07K 16/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
32against translation products of oncogenes
C07K 16/468
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
C07K 2317/31
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
31multispecific
C07K 2317/35
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
35Valency
C07K 2317/524
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
52Constant or Fc region; Isotype
524CH2 domain
Applicants
  • UNIVERSITÄT STUTTGART [DE]/[DE]
Inventors
  • KONTERMANN, Roland
  • SEIFERT, Oliver
Agents
  • ZWICKER, Jörk
Priority Data
19199639.625.09.2019EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BINDING MODULES COMPRISING MODIFIED EHD2 DOMAINS
(FR) MODULES DE LIAISON COMPRENANT DES DOMAINES EHD2 MODIFIÉS
Abstract
(EN)
The present invention relates to binding molecules comprising two polypeptide chains, wherein the peptide chains comprise modified EHD2 domains allowing heterodimerization only, thereby preventing homodimers, nucleic acids encoding such binding molecules and uses of such binding molecules or nucleic acids encoding such binding molecules in therapy.
(FR)
La présente invention concerne des molécules de liaison comprenant deux chaînes polypeptidiques, les chaînes peptidiques comprenant des domaines EHD2 modifiés permettant une hétérodimérisation uniquement, empêchant ainsi des homodimères, des acides nucléiques codant pour de telles molécules de liaison et des utilisations de telles molécules de liaison ou d'acides nucléiques codant pour de telles molécules de liaison en thérapie.
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