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1. WO2021057256 - HETEROCYCLIC NITROGEN COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, PREPARATION METHOD THEREFOR AND USE THEREOF

Publication Number WO/2021/057256
Publication Date 01.04.2021
International Application No. PCT/CN2020/106080
International Filing Date 31.07.2020
IPC
C07D 495/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/4365 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
4365the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
A61K 31/444 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
444containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/4365
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
4365the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
A61K 31/444
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
444containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 495/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • 四川科伦博泰生物医药股份有限公司 SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. [CN]/[CN]
Inventors
  • 游泽金 YOU, Zejin
  • 何云 HE, Yun
  • 田强 TIAN, Qiang
  • 宋宏梅 SONG, Hongmei
  • 薛彤彤 XUE, Tongtong
  • 王晶翼 WANG, Jingyi
Agents
  • 北京林达刘知识产权代理事务所(普通合伙) LINDA LIU & PARTNERS
Priority Data
201910932795.229.09.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) HETEROCYCLIC NITROGEN COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, PREPARATION METHOD THEREFOR AND USE THEREOF
(FR) COMPOSÉ AZOTÉ HÉTÉROCYCLIQUE, COMPOSITION PHARMACEUTIQUE LE CONTENANT, SON PROCÉDÉ DE PRÉPARATION ET UTILISATION ASSOCIÉE
(ZH) 一种含氮并环类化合物,包含其的药物组合物,其制备方法及其用途
Abstract
(EN)
The present invention falls within the field of medicinal chemistry, and relates to a heterocyclic nitrogen compound, and a pharmaceutical composition containing same, a preparation method therefor and a use thereof. In particular, provided in the present invention is a compound of the structure of formula II, which compound has a significant NLRP3 regulation effect, can be used as an efficient NLRP3 regulator, and has an anti-tumour activity.
(FR)
La présente invention s'inscrit dans le domaine de la chimie médicinale, et concerne un composé azoté hétérocyclique, et une composition pharmaceutique le contenant, son procédé de préparation et une utilisation associée. En particulier, la présente invention concerne un composé de la structure de formule II, lequel composé a un effet de régulation de NLRP3 significatif, peut être utilisé en tant que régulateur de NLRP3 efficace et a une activité antitumorale.
(ZH)
本发明属于药物化学领域,涉及一种含氮并环类化合物,包含其的药物组合物,其制备方法及其用途。具体而言,本发明提供了一种具有式II结构的化合物,其具有显著的NLRP3调节作用,可以作为高效的NLRP3调节剂,具有抗肿瘤活性。
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