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1. WO2021056118 - COMPOSITIONS AND METHODS FOR DIAGNOSIS OF PERIPHERAL ARTERIAL DISEASE

Publication Number WO/2021/056118
Publication Date 01.04.2021
International Application No. PCT/CA2020/051287
International Filing Date 25.09.2020
IPC
G01N 33/48 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
C12Q 1/68 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
C40B 30/00 2006.01
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
30Methods of screening libraries
C40B 40/10 2006.01
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40Libraries per se, e.g. arrays, mixtures
04Libraries containing only organic compounds
10Libraries containing peptides or polypeptides, or derivatives thereof
G16B 25/10 2019.01
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
25ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
10Gene or protein expression profiling; Expression-ratio estimation or normalisation
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
C07K 14/4756
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
4756Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
C07K 14/70567
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70567Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
C40B 30/00
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
30Methods of screening libraries
C40B 40/10
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40Libraries per se, e.g. arrays, mixtures
04Libraries containing only organic compounds
10Libraries containing peptides or polypeptides, or derivatives thereof
G01N 33/48
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
G16B 25/10
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
25ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
10Gene or protein expression profiling; Expression-ratio estimation or normalisation
Applicants
  • UNITY HEALTH TORONTO [CA]/[CA]
Inventors
  • QADURA, Mohammad
Agents
  • LOWTHERS, Erica L.
  • MCMANUS, Kimberly A.
  • SINDEN, William K.
  • REECE, Pia-Lauren
  • BARTOSZEWICZ, Lola A.
  • SABETA, Anton C.
  • CHEUNG, SuMei
Priority Data
62/906,98427.09.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR DIAGNOSIS OF PERIPHERAL ARTERIAL DISEASE
(FR) COMPOSITIONS ET MÉTHODES DE DIAGNOSTIC D'UNE MALADIE ARTÉRIELLE PÉRIPHÉRIQUE
Abstract
(EN)
Described herein is fatty acid-binding protein 3 (FABP3) and/or FABP4 for diagnosing or staging peripheral artery disease (PAD) or for assessing revascularization in PAD afflicted subjects. Also described is FABP3 and/or FABP4 for distinguishing PAD patients from non-PAD patients regardless of the presence PAD symptoms, for distinguishing PAD patients with a non-compressible ABI from non-PAD patients, or for determining prognosis in PAD. Also described herein are various methods and biomarker panels for use in PAD.
(FR)
La présente invention concerne une protéine 3 de liaison à l'acide gras (FABP3) et/ou des FABP4 pour le diagnostic ou la stadification d'une maladie artérielle périphérique (PAD) ou pour l'évaluation de la revascularisation chez des sujets atteints d'une PAD. L'invention concerne également des FABP3 et/ou des FABP4 pour distinguer des patients atteints d'une PAD de patients non atteints d'une PAD indépendamment de la présence de symptômes d'une PAD, pour distinguer des patients atteints d'une PAD avec un ABI non compressible des patients non atteints d'une PAD, ou pour déterminer un pronostic dans le cadre d'une PAD. L'invention concerne également divers procédés et panels de biomarqueurs destinés à être utilisés dans le cadre d'une PAD.
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