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1. WO2021050059 - DNA-PK INHIBITING COMPOUNDS

Publication Number WO/2021/050059
Publication Date 18.03.2021
International Application No. PCT/US2019/050577
International Filing Date 11.09.2019
IPC
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 519/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
A61K 31/4375 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
4375the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 519/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applicants
  • PROVINCIAL HEALTH SERVICES AUTHORITY [CA]/[CA]
  • MINCHINTON, Andrew, Ivor [CA]/[CA]
  • KYLE, Alastair, Hugh [CA]/[CA]
  • EVANS, James [US]/[US]
  • MANN, Samuel, Edward [GB]/[GB]
  • HYND, George [GB]/[GB]
Inventors
  • MINCHINTON, Andrew, Ivor
  • KYLE, Alastair, Hugh
  • EVANS, James
  • MANN, Samuel, Edward
  • HYND, George
Agents
  • ESKER, Todd, W.
  • BEARDELL, Louis
  • KWAK, Byung, Cheol
  • GE, Xinguan
  • ANTCZAK, Andrew, J.
Priority Data
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DNA-PK INHIBITING COMPOUNDS
(FR) COMPOSÉS INHIBITEURS DE L'ADN-PK
Abstract
(EN) The present disclosure relates to DNA-PK inhibiting compounds and prodrugs thereof that are useful in the treatment of diseases, including cancer. In particular, the compounds sensitise cancers to therapies such as chemotherapy and radiotherapy.
(FR) La présente invention concerne des composés inhibiteurs d'ADN-PK et des promédicaments de ceux-ci qui sont utiles dans le traitement de maladies, y compris le cancer. En particulier, les composés sensibilisent les cancers à des thérapies telles que la chimiothérapie et la radiothérapie.
Related patent documents
EP2019773688This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
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