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1. WO2021045969 - HEPATITIS B VIRUS VACCINES

Publication Number WO/2021/045969
Publication Date 11.03.2021
International Application No. PCT/US2020/048411
International Filing Date 28.08.2020
IPC
C07K 14/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
01DNA viruses
02Hepadnaviridae, e.g. hepatitis B virus
CPC
A61K 2039/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
545characterised by the dose, timing or administration schedule
A61K 2039/57
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
57characterised by the type of response, e.g. Th1, Th2
A61K 2039/572
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
57characterised by the type of response, e.g. Th1, Th2
572cytotoxic response
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61P 31/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
Applicants
  • VIR BIOTECHNOLOGY, INC. [US]/[US]
  • TRIAD NATIONAL SECURITY, LLC [US]/[US]
Inventors
  • BRUENING, Eric
  • DOUGLAS, Janet
  • MARSHALL, Emily
  • YUSIM, Karina
  • KORBER, Bette
  • THEILER, James
Agents
  • SARGEANT, Brooke
  • OBEIDAT, Baha, A.
  • KUMABE, Blake, K.
  • SOLTANI, Bobby, B.
  • ZENTZ, Bradley, J.
  • QUIST, Brooke, W.
  • ROTH, Carol, J.
  • EIDT, Chandra, E.
  • WITTKOPP, Cristina, J.
  • O'BRIEN, Daniel
  • CARLSON, David, V.
  • CHEN, David W.
  • CONLEE, David C.
  • STARK, Duncan
  • SUN, Eileen, S.
  • HARWOOD, Eric, A.
  • GERTZ, Glenda, A.
  • HAN, Hai
  • TALBERT, Hayley, J.
  • BARRETT, Jared, M.
  • MIXCO, Javier, M.
  • DANLEY, Jeffrey E.
  • SAKOI, Jeffrey, M.
  • SEO, Jeong Hee
  • BAUNACH, Jeremiah, J.
  • ZHANG, Jianping
  • MORGAN, John, A.
  • WAKELEY, John, J.
  • COE, Justin, E.
  • HENCKEL, Karen, M.
  • HEFTER, Karl, A.
  • HERMANNS, Karl, R.
  • CLAYTON, Kenneth W.
  • MORGAN, Kevan, L.
  • COSTANZA, Kevin, S.
  • COOPER, Michael, P.
  • BENDEMIRE, Paul D.
  • LIN, Qing
  • HALLER, Rachel, A.
  • IANNUCCI, Robert
  • TARLETON, E., Russell
  • WEBB, Samuel, E.
  • LIU, Shi
  • LEEK, Shoko, I.
  • ROSENMAN, Stephen, J.
  • LAWRENZ, Steven, D.
  • ABEDI, Syed
  • SHEWMAKE, Thomas, A.
  • BOLLER, Timothy, L.
  • CANTRELL, Tyler, C.
  • LI, Yiheng
  • SAKOI, Zachary M.
Priority Data
62/893,54629.08.2019US
62/941,12527.11.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HEPATITIS B VIRUS VACCINES
(FR) VACCINS CONTRE LE VIRUS DE L'HÉPATITE B
Abstract
(EN)
The present disclosure relates to isolated polynucleotides and polypeptides, and related hepatitis B virus (HBV) vaccines. The present disclosure also relates to viral vectors for expressing such polypeptides, and which may be used in HBV vaccines, as well as methods of protecting a subject from HBV infection and methods of treating HBV in a subject comprising administering the polypeptides, vectors, or vaccines described herein. Methods of designing and producing an HBV vaccine comprising designing vaccine antigens to cover the diversity within a geographic area using an antigen amino acid sequence that efficiently covers the epitopes in the HBV genotypes present in the geographic area are also provided herein.
(FR)
La présente invention concerne des polynucléotides et des polypeptides isolés, et des vaccins contre le virus de l'hépatite B (VHB) associés. La présente invention concerne également des vecteurs viraux pour exprimer de tels polypeptides, et qui peuvent être utilisés dans des vaccins contre le VHB, ainsi que des procédés de protection d'un sujet contre une infection par le VHB et des procédés de traitement du VHB chez un sujet comprenant l'administration des polypeptides, des vecteurs ou des vaccins décrits dans l'invention. L'invention concerne également des procédés de conception et de production d'un vaccin contre le VHB comprenant la conception d'antigènes vaccinaux pour couvrir la diversité dans une zone géographique à l'aide d'une séquence d'acides aminés d'antigène qui couvre efficacement les épitopes dans les génotypes du VHB présents dans la zone géographique.
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