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1. WO2021041858 - DIFFERENTIATED TENDON CELLS DERIVED FROM PLURIPOTENT PROGENITOR CELLS AND METHODS OF USE THEREOF

Publication Number WO/2021/041858
Publication Date 04.03.2021
International Application No. PCT/US2020/048474
International Filing Date 28.08.2020
IPC
A61K 35/32 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61K 38/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
A61L 27/54 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
54Biologically active materials, e.g. therapeutic substances
A61P 19/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
CPC
A61K 35/32
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61K 38/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
A61L 27/3834
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
38containing added animal cells
3804characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
3834Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
A61L 27/386
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
38containing added animal cells
3839characterised by the site of application in the body
3843Connective tissue
386Ligaments, tendons
Applicants
  • ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI [US]/[US]
Inventors
  • KAJI, Deepak
  • HUANG, Alice, H.
Agents
  • MACLEOD, Janet, M.
  • FOIT, Linda
  • BARRISON, Flynn
Priority Data
62/893,46929.08.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DIFFERENTIATED TENDON CELLS DERIVED FROM PLURIPOTENT PROGENITOR CELLS AND METHODS OF USE THEREOF
(FR) CELLULES DE TENDON DIFFÉRENCIÉES DÉRIVÉES DE CELLULES PROGÉNITRICES PLURIPOTENTES ET PROCÉDÉS D’UTILISATION DE CELLES-CI
Abstract
(EN)
The present disclosure relates generally to differentiated tendon cells derived from pluripotent stem cells and methods of making and using such cells. In one aspect, provided is a method of generating a population of tenocytes comprising: (a) culturing multipotent mesoderm in serum-free medium in the presence of transforming growth factor P (TGFP) and optionally one or more of fibroblast growth factor (FGF), sonic hedgehog (SHH), smoothened agonist (SAG), Noggin, Activin A, growth differentiation factor 7 (GDF7), CD1530, and LDN-193189 to produce tenocytes, and (b) optionally isolating the tenocytes.
(FR)
La présente invention concerne généralement des cellules de tendon différenciées dérivées de cellules souches pluripotentes et des procédés de fabrication et d’utilisation de telles cellules. Selon un aspect, l’invention concerne un procédé de génération d’une population de ténocytes comprenant : (a) la culture de mésoderme multipotent dans un milieu sans sérum en présence de facteur de croissance transformant P (TGFP) et facultativement l’un ou plusieurs parmi le facteur de croissance des fibroblastes (FGF), Sonic hedgehog (SHH), un agoniste de Smoothened (SAG), la noggine, l’activine A, le facteur de différenciation de croissance 7 (GDF7), CD1530 et LDN-193189 pour produire des ténocytes, et (b) éventuellement l'isolation des ténocytes.
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