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1. WO2021041667 - MODIFYING MESSAGES STORED IN MIXTURES OF MOLECULES USING THIN-LAYER CHROMATOGRAPHY

Publication Number WO/2021/041667
Publication Date 04.03.2021
International Application No. PCT/US2020/048190
International Filing Date 27.08.2020
IPC
G01N 30/90 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
90Plate chromatography, e.g. thin layer or paper chromatography
B01J 19/00 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
C12Q 1/68 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
G06K 19/00 2006.1
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
KRECOGNITION OF DATA; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
19Record carriers for use with machines and with at least a part designed to carry digital markings
G09C 1/00 2006.1
GPHYSICS
09EDUCATING; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
CCIPHERING OR DECIPHERING APPARATUS FOR CRYPTOGRAPHIC OR OTHER PURPOSES INVOLVING THE NEED FOR SECRECY
1Apparatus or methods whereby a given sequence of signs, e.g. an intelligible text, is transformed into an unintelligible sequence of signs by transposing the signs or groups of signs or by replacing them by others according to a predetermined system
G11B 7/241 2006.1
GPHYSICS
11INFORMATION STORAGE
BINFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
7Recording or reproducing by optical means, e.g. recording using a thermal beam of optical radiation, reproducing using an optical beam at lower power; Record carriers therefor
24Record carriers characterised by shape, structure or physical properties, or by the selection of the material 
241Record carriers characterised by the selection of the material
CPC
B01J 2219/00605
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00583Features relative to the processes being carried out
00603Making arrays on substantially continuous surfaces
00605the compounds being directly bound or immobilised to solid supports
B01J 2219/00659
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00583Features relative to the processes being carried out
00603Making arrays on substantially continuous surfaces
00659Two-dimensional arrays
B01J 2219/00695
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
0068Means for controlling the apparatus of the process
00695Synthesis control routines, e.g. using computer programs
B01J 2219/00725
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00718Type of compounds synthesised
0072Organic compounds
00725Peptides
G01N 30/90
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography ; or field flow fractionation;
90Plate chromatography, e.g. thin layer or paper chromatography
G06K 19/06037
GPHYSICS
06COMPUTING; CALCULATING; COUNTING
KRECOGNITION OF DATA; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
19Record carriers for use with machines and with at least a part designed to carry digital markings
06characterised by the kind of the digital marking, e.g. shape, nature, code
06009with optically detectable marking
06037multi-dimensional coding
Applicants
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US]/[US]
Inventors
  • WHITESIDES, George, M.
  • WONG, Albert, Siangyoong
  • FINK, Michael, Johannes
  • MOHAMED, Khaled, Abdelazim
Agents
  • AKHIEZER, Alexander
  • MI, Cai
  • ABELLEIRA, Usan, M.
  • ALEXANDER, Akhiezer
  • CHATTERLEY, Alexander, J.
Priority Data
62/892,17127.08.2019US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MODIFYING MESSAGES STORED IN MIXTURES OF MOLECULES USING THIN-LAYER CHROMATOGRAPHY
(FR) MODIFICATION DE MESSAGES STOCKÉS DANS DES MÉLANGES DE MOLÉCULES À L'AIDE D'UNE CHROMATOGRAPHIE SUR COUCHE MINCE
Abstract
(EN) Storage media and methods of reading data from and writing data to said storage media are provided. Information is stored as a mixture of small molecules (MolBits), arranged in an array of addressable locations on a substrate. The mixture comprises at least two subsets of molecules being identifiable by different properties thereof. In one embodiment, the information stored in the mixture (1-16) is decoded by a first step of separating subsets of Molbits having different retardation factors (Rf, I - VIII) on a thin layer chromatography plate. In a second step the separated subsets (4, 15; 10, 16) can be readout differently using various visualization methods adapted to the different properties. Each MolBit is uniquely associated with a predetermined position in a numerical value, wherein the presence of the Molbit in the mixture indicates a predetermined digit at the associated position and the absence of said molecule in the mixture indicates a zero at said associated position.
(FR) L'invention concerne des supports de stockage et des procédés de lecture de données à partir desdits supports de stockage et d'écriture de données sur ceux-ci. Des informations sont stockées en tant que mélange de petites molécules (MolBits), disposées dans un réseau d'emplacements adressables sur un substrat. Le mélange comprend au moins deux sous-ensembles de molécules pouvant être identifiées par les différentes propriétés de celles-ci. Dans un mode de réalisation, les informations stockées dans le mélange (1-16) sont décodées par une première étape de séparation de sous-ensembles de Molbits ayant différents facteurs de retard (Rf, I-VIII) sur une plaque de chromatographie sur couche mince. Dans une seconde étape, les sous-ensembles séparés (4, 15 ; 10, 16) peuvent être lus différemment à l'aide de diverses méthodes de visualisation adaptées aux différentes propriétés. Chaque MolBit est associé de manière unique à un emplacement prédéterminé dans une valeur numérique, la présence du MolBit dans le mélange indiquant un chiffre prédéterminé au niveau de l'emplacement associé et l'absence de ladite molécule dans le mélange indiquant un zéro au niveau dudit emplacement associé.
Latest bibliographic data on file with the International Bureau