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1. WO2021041469 - METHOD AND APPARATUS FOR INDIVIDUALIZED ADMINISTRATION OF MEDICAMENTS FOR ENHANCED SAFE DELIVERY WITHIN A THERAPEUTIC RANGE

Publication Number WO/2021/041469
Publication Date 04.03.2021
International Application No. PCT/US2020/047889
International Filing Date 26.08.2020
IPC
A61B 5/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
CPC
A61B 5/4839
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
48Other medical applications
4836Diagnosis combined with treatment in closed-loop systems or methods
4839combined with drug delivery
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
G16H 20/10
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
20ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
10relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 50/30
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
30for calculating health indices; for individual health risk assessment
Applicants
  • UNIVERSITY OF MARYLAND, BALTIMORE [US]/[US]
Inventors
  • RACKAUCKAS, Christopher Vincent
  • IVATURI, Vijay
Agents
  • MOLINELLI, Eugene J.
Priority Data
62/891,60226.08.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD AND APPARATUS FOR INDIVIDUALIZED ADMINISTRATION OF MEDICAMENTS FOR ENHANCED SAFE DELIVERY WITHIN A THERAPEUTIC RANGE
(FR) PROCÉDÉ ET APPAREIL D'ADMINISTRATION INDIVIDUALISÉE DE MÉDICAMENTS POUR UNE ADMINISTRATION À SÉCURITÉ AMÉLIORÉE AU SEIN D'UNE PLAGE THÉRAPEUTIQUE
Abstract
(EN)
Techniques for generating a dosing protocol for an individual include receiving first and second and third data. First data indicates, for dose response to a medicament, a continuous multivariate model with at least one distribution parameter characterizing variations in the population. Second data indicates a therapeutic range of values for the dose response. Third data indicates a cost function based on distance of a dose response from the therapeutic range. The method includes evaluating for a candidate dose an expected cost based at least in part on the distribution parameter and a Koopman transform of the cost function. When the expected cost is less than a threshold cost, the candidate dose of the medicament is administered to a subject.
(FR)
Selon l'invention, des techniques de génération d'un protocole de dosage pour un individu consistent à recevoir des premières et deuxièmes et troisièmes données. Les premières données indiquent, pour une dose-réponse à un médicament, un modèle à variables multiples continu présentant au moins un paramètre de distribution caractérisant des variations dans la population. Les deuxièmes données indiquent une plage thérapeutique de valeurs correspondant à la dose-réponse. Les troisièmes données indiquent une fonction de coût sur la base de la distance d'une dose-réponse de la plage thérapeutique. Le procédé consiste à évaluer, pour une dose candidate d'un coût attendu sur la base, au moins en partie, le paramètre de distribution et une transformée Koopman de la fonction de coût. Lorsque le coût attendu est inférieur à un coût seuil, la dose candidate du médicament est administrée à un sujet.
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