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1. WO2021038637 - NOVEL VITAMIN A DERIVATIVE AND METHOD FOR PRODUCING SAME

Publication Number WO/2021/038637
Publication Date 04.03.2021
International Application No. PCT/JP2019/033112
International Filing Date 23.08.2019
IPC
C07C 49/573 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
49Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
527Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
573containing hydroxy groups
C07C 45/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
45Preparation of compounds having C=O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
27by oxidation
30with halogen containing compounds, e.g. hypohalogenation
C07C 67/297 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
67Preparation of carboxylic acid esters
28by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
297by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
C07C 69/007 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
007Esters of unsaturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
C07C 69/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
02Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
12Acetic acid esters
16of dihydroxylic compounds
CPC
A61K 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
A61K 31/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
A61K 8/67
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
67Vitamins
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
Applicants
  • リファインホールディングス株式会社 REFINE HOLDINGS CO., LTD. [JP]/[JP]
Inventors
  • 坪井 誠 TSUBOI Makoto
  • 岩▲崎▼ 洋 IWASAKI Hiroshi
  • 彼谷 邦光 KAYA Kunimitsu
  • 和田 昭盛 WADA Akimori
  • 山野 由美子 YAMANO Yumiko
Agents
  • めぶき国際特許業務法人 MEBUKI IP LAW FIRM
  • 長谷川 洋 HASEGAWA Hiroshi
Priority Data
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) NOVEL VITAMIN A DERIVATIVE AND METHOD FOR PRODUCING SAME
(FR) NOUVEAU DÉRIVÉ DE VITAMINE A ET SON PROCÉDÉ DE PRODUCTION
(JA) 新規ビタミンA誘導体およびその製造方法
Abstract
(EN)
Provided are: a novel vitamin A derivative which is useful as a medicinal drug and a cosmetic and which comprises a compound represented by formula (I) or formula (II) (in the formulae, R1 and R2 each independently denote a hydrogen atom, an alkyl group having 1-12 carbon atoms, an alkenyl group having 2-10 carbon atoms, an alkynyl group having 2-10 carbon atoms or an acyl group having 2-30 carbon atoms), or a salt thereof; and a method for producing same.
(FR)
L'invention concerne : un nouveau dérivé de la vitamine A qui est utile en tant que médicament médicinal et produit cosmétique et qui comprend un composé représenté par la formule (I) ou la formule (II) (dans les formules, R1 et R2 représentent chacun indépendamment un atome d'hydrogène, un groupe alkyle ayant de 1 à 12 atomes de carbone, un groupe alcényle ayant de 2 à 10 atomes de carbone, un groupe alcynyle ayant de 2 à 10 atomes de carbone ou un groupe acyle ayant de 2 à 30 atomes de carbone), ou un sel de celui-ci ; et un procédé de production associé.
(JA)
下記式(I): または式(II): (式中、R、Rは、互いに独立して、水素原子、炭素数1~12のアルキル基、炭素数2~10のアルケニル基、炭素数2~10のアルキニル基、または炭素数2~30のアシル基を示す。)で表される化合物またはその塩からなる、医薬品および化粧品として有用な、新規ビタミンA誘導体およびその製造方法を提供する。
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