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1. WO2021038480 - COMBINATIONS FOR TREATING INFLUENZA VIRUS

Publication Number WO/2021/038480
Publication Date 04.03.2021
International Application No. PCT/IB2020/058000
International Filing Date 27.08.2020
IPC
A61K 31/506 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
A61K 31/5383 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
5383ortho- or peri-condensed with heterocyclic ring systems
A61P 31/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
CPC
A61K 31/506
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
A61K 31/5383
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
5383ortho- or peri-condensed with heterocyclic ring systems
A61P 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
Applicants
  • JANSSEN PHARMACEUTICALS, INC. [US]/[US]
Inventors
  • WU, Jin
  • VINGERHOETS, Johan Hendrika Jozef
  • ROYMANS, Dirk André Emmy
Priority Data
62/892,13327.08.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMBINATIONS FOR TREATING INFLUENZA VIRUS
(FR) ASSOCIATION POUR LE TRAITEMENT DU VIRUS DE LA GRIPPE
Abstract
(EN)
The present invention relates to combinations comprising Compound (1) and baloxavir or a prodrug thereof. The present invention also relates to pharmaceutical compositions comprising a combination of Compound (1) and baloxavir, as well as processes for producing the pharmaceutical compositions. The invention further relates to methods of treating influenza virus infection in a subject or biological sample infected with influenza viruses, as well as methods of inhibiting the replication of, or reducing the number of influenza viruses in an in vitro biological sample.
(FR)
La présente invention concerne des associations comprenant le composé (1) et le baloxavir ou un promédicament de celui-ci. La présente invention concerne également des compositions pharmaceutiques comprenant une association du composé (1) et du baloxavir, ainsi que des procédés de production des compositions pharmaceutiques. L'invention concerne en outre des procédés de traitement d'une infection par le virus de la grippe chez un sujet ou un échantillon biologique infecté par des virus de la grippe, ainsi que des procédés d'inhibition de la réplication ou de réduction du nombre de virus de la grippe dans un échantillon biologique in vitro.
Latest bibliographic data on file with the International Bureau