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1. WO2021037755 - DETOMIDINE HYDROCHLORIDE MONOHYDRATE

Publication Number WO/2021/037755
Publication Date 04.03.2021
International Application No. PCT/EP2020/073549
International Filing Date 21.08.2020
IPC
C07D 233/64 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
64with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
A61P 25/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
20Hypnotics; Sedatives
A61K 31/4174 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
4174Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
CPC
A61P 25/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
20Hypnotics; Sedatives
C07D 233/64
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
64with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
Applicants
  • SACHSE, Andreas [DE]/[DE]
Inventors
  • SACHSE, Andreas
Agents
  • SCHUBERT, Klemens
Priority Data
19193476.923.08.2019EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DETOMIDINE HYDROCHLORIDE MONOHYDRATE
(FR) MONOHYDRATE DE CHLORHYDRATE DE DÉTOMIDINE
Abstract
(EN)
The present invention relates to detomidine hydrochloride monohydrate, a method for the production of the same and to the use of the same as a medicament, that is for use as anesthetic, analgesic, muscle relaxant, sedative and any other condition susceptible to treatment with an alpha2- adrenoreceptor agonist in a mammal. Detomidine hydrochloride monohydrate described herein represents the pure monohydrate form which additionally shows a high purity reflected the very low content of impurities and especially residual solvents. Correspondingly, detomidine hydrochloride monohydrate described herein, shows a very high storage stability which is useful for the production of pharmaceutical compositions for the treatment of pathological conditions.
(FR)
La présente invention concerne du monohydrate de chlorhydrate de détomidine, un procédé pour la production de celui-ci et l'utilisation de celui-ci en tant que médicament, destiné à être utilisé comme anesthésique, analgésique, myorelaxant, sédatif et tout autre état susceptible d'être traité avec un agoniste du récepteur adrénergique alpha2 chez un mammifère. Le monohydrate de chlorhydrate de détomidine selon l'invention représente la forme monohydrate pure qui montre en outre une grande pureté reflétant la très faible teneur en impuretés et en particulier en solvants résiduels. De manière correspondante, le monohydrate de chlorhydrate de détomidine selon la présente invention a une très grande stabilité au stockage qui est utile pour la production de compositions pharmaceutiques destinées au traitement d'états pathologiques.
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