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1. WO2021037292 - POLYPEPTIDE AND USE THEREOF

Publication Number WO/2021/037292
Publication Date 04.03.2021
International Application No. PCT/CN2020/123555
International Filing Date 26.10.2020
IPC
C07K 7/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
08having 12 to 20 amino acids
A61K 38/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
10Peptides having 12 to 20 amino acids
A61P 11/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 1/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 17/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 19/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
Applicants
  • 南京安吉生物科技有限公司 NANJING ANJI BIOLOGICAL TECHNOLOGY CO., LTD [CN]/[CN]
Inventors
  • 康志安 KANG, Zhian
Agents
  • 江苏瑞途律师事务所 RAYTO PARTNERS, P.C.
Priority Data
201910799291.827.08.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) POLYPEPTIDE AND USE THEREOF
(FR) POLYPEPTIDE ET SON UTILISATION
(ZH) 一种多肽及其应用
Abstract
(EN)
Disclosed is a use of a polypeptide, relating to the bio-pharmaceutical field. A polypeptide characterized in that the domain comprised in the polypeptide is Pro-Arg-Cys-X-Y-Gly-Glu, where X is Trp or Tyr and Y is Arg or Cys, or Arg-Gly-Ala-Asp-Arg-Ala. The present invention can treat different fibrosis diseases and medical conditions, including pulmonary fibrosis, hepatic fibrosis, marrow fibrosis, kidney fibrosis, cardiac fibrosis, skin fibrosis, and lung tissue lesion.
(FR)
L'invention concerne l'utilisation d'un polypeptide, se rapportant au domaine bio-pharmaceutique. L'invention concerne un polypeptide caractérisé en ce que le domaine compris dans le polypeptide est Pro-Arg-Cys-X-Y-Gly-Glu, expression dans laquelle X est Trp ou Tyr et Y est Arg ou Cys, ou Arg-Gly-Ala-Asp-Arg-Ala, ou des séquences ayant lesdits domaines ayant des acides aminés quelconques mutés. La présente invention peut traiter différentes maladies et affections médicales de fibrose, y compris la fibrose pulmonaire, la fibrose hépatique, la fibrose de la moelle, la fibrose rénale, la fibrose cardiaque, la fibrose de la peau et la lésion des tissus pulmonaires.
(ZH)
本发明提供了一种多肽及其应用,属于生物制药领域。该多肽中含有的结构域Pro-Arg-Cys-X-Y-Gly-Glu和Arg-Gly-Ala-Asp-Arg-Ala,其中X是Trp或Tyr,Y是Arg或Cys;可以治疗各种纤维化疾病及病状,包括肺纤维化、肝纤维化、骨髓纤维化、肾纤维化和心肌纤维化、皮肤纤维化以及肺部组织病变。
Also published as
Latest bibliographic data on file with the International Bureau