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1. WO2021037291 - FUSION POLYPEPTIDE HAVING MULTIFUNCTIONAL ACTIVITIES AND USE THEREOF

Publication Number WO/2021/037291
Publication Date 04.03.2021
International Application No. PCT/CN2020/123553
International Filing Date 26.10.2020
IPC
C07K 19/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
A61K 38/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61P 11/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 1/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 13/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
Applicants
  • 南京安吉生物科技有限公司 NANJING ANJI BIOLOGICAL TECHNOLOGY CO., LTD [CN]/[CN]
Inventors
  • 康志安 KANG, Zhian
Agents
  • 江苏瑞途律师事务所 RAYTO PARTNERS, P.C.
Priority Data
201910796360.X27.08.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) FUSION POLYPEPTIDE HAVING MULTIFUNCTIONAL ACTIVITIES AND USE THEREOF
(FR) POLYPEPTIDE DE FUSION AYANT DES ACTIVITÉS MULTIFONCTIONNELLES ET SON UTILISATION
(ZH) 具有多功能活性的融合多肽及其应用
Abstract
(EN)
Provided is a fusion polypeptide having multifunctional activities, the amino acid sequence of the fusion polypeptide being: Pro-Arg-Cys-X-Y-Gly-Glu-Gly-Gly-Gly-Gly-Ile-Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro-Gly-Gly-Gly-Gly-Arg-Gly-Asp, where X is Trp or Tyr and Y is Arg or Cys. The fusion polypeptide may be used to treat various fibrosis diseases and lung tissue lesions.
(FR)
L'invention concerne l'utilisation d'un polypeptide de fusion ayant des activités multifonctionnelles. Le polypeptide de fusion ayant des activités multifonctionnelles est caractérisé en ce que le polypeptide comprend le domaine suivant: Pro-Arg-Cys-X-Y-Gly-Glu, où X représente Trp ou Tyr et Y représente Arg ou Cys, ou Gly-Gly-Gly-Ile-Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro-Gly-Gly-Gly-Gly-Arg-Gly-Asp, ou des séquences ayant lesdits domaines ayant des acides aminés quelconques mutés. La présente invention peut traiter différentes maladies de fibrose et affections médicales comprenant la fibrose pulmonaire, la fibrose hépatique, la fibrose de la peau, la fibrose rénale, la fibrose cardiaque et la lésion de tissu pulmonaire.
(ZH)
本发明提供了具有多功能活性的融合多肽,该融合多肽的氨基酸序列为:Pro-Arg-Cys-X-Y-Gly-Glu-Gly-Gly-Gly-Gly-Ile-Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro-Gly-Gly-Gly-Gly-Arg-Gly-Asp,其中X是Trp或Tyr,Y是Arg或Cys。本发明的融合多肽可用于治疗各种纤维化疾病及肺部组织病变。
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Latest bibliographic data on file with the International Bureau