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1. WO2021037127 - BENZIMIDAZOLE SUBSTITUTION-BASED PHENYL N-BUTYRAMIDE COMPOUND AND PREPARATION METHOD THEREFOR

Publication Number WO/2021/037127
Publication Date 04.03.2021
International Application No. PCT/CN2020/111668
International Filing Date 27.08.2020
IPC
C07D 235/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
235Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02condensed with carbocyclic rings or ring systems
04Benzimidazoles; Hydrogenated benzimidazoles
18with aryl radicals directly attached in position 2
CPC
C07D 235/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
235Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02condensed with carbocyclic rings or ring systems
04Benzimidazoles; Hydrogenated benzimidazoles
18with aryl radicals directly attached in position 2
Applicants
  • 上海特化医药科技有限公司 TOPHARMAN SHANGHAI CO., LTD. [CN]/[CN]
  • 中国科学院上海药物研究所 SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES [CN]/[CN]
  • 山东福长药业有限公司 TOPHARMAN TANCHENG CO., LTD. [CN]/[CN]
Inventors
  • 沈敬山 SHEN, Jingshan
  • 孙长亮 SUN, Changliang
  • 朱富强 ZHU, Fuqiang
  • 张骏驰 ZHANG, Junchi
  • 李锐 LI, Rui
Agents
  • 北京金信知识产权代理有限公司 KINGSOUND & PARTNERS
Priority Data
201910807292.229.08.2019CN
202010863046.125.08.2020CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) BENZIMIDAZOLE SUBSTITUTION-BASED PHENYL N-BUTYRAMIDE COMPOUND AND PREPARATION METHOD THEREFOR
(FR) COMPOSÉ DE PHÉNYL N-BUTYRAMIDE BASÉ SUR LA SUBSTITUTION DE BENZIMIDAZOLE ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 基于苯并咪唑取代的苯基正丁酰胺的化合物及其制备方法
Abstract
(EN)
The present disclosure relates to a benzimidazole substitution-based phenyl n-butyramide compound and a preparation method therefor. The method of the present disclosure avoids a nitration and polyphosphoric acid cyclization reaction, and avoids the production of a large amount of waste acid reaction liquid from the source. The synthesis method embodied in the present invention has the advantages of being simple and highly efficient, having mild conditions and producing less pollutants, and so on, and is suitable for development as a green and sustainable production process.
(FR)
La présente invention concerne un composé de phényl n-butyramide basé sur la substitution de benzimidazole et son procédé de préparation. Le procédé de la présente invention évite une réaction de cyclisation d'acide polyphosphorique et de nitration, et évite la production d'une grande quantité de liquide de réaction d'acide épuisé provenant de la source. Le procédé de synthèse selon la présente invention présente les avantages d'être simple et très efficace, ayant des conditions douces et produisant moins de polluants, et ainsi de suite, et est approprié pour le développement en tant que procédé de production écologique et durable.
(ZH)
本公开涉及基于苯并咪唑取代的苯基正丁酰胺的化合物及其制备方法。本公开的方法避免了硝化和多聚磷酸环合反应,从源头上避免了大量废酸反应液的产生。本发明所体现的合成方法具有简单高效、条件温和污染物少等优点,适于开发为绿色可持续性的生产工艺。
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