Processing

Please wait...

Settings

Settings

Goto Application

1. WO2021036514 - PPAR γ/δ DUAL AGONIST, PREPARATION METHOD THEREOF AND USE THEREOF IN PREPARING A DRUG

Publication Number WO/2021/036514
Publication Date 04.03.2021
International Application No. PCT/CN2020/100518
International Filing Date 07.07.2020
IPC
C07D 307/83 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77ortho- or peri-condensed with carbocyclic rings or ring systems
78Benzo furans; Hydrogenated benzo furans
82with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
83Oxygen atoms
A61P 3/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
A61P 3/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 1/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
CPC
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants
  • 广东药科大学 GUANGDONG PHARMACEUTICAL UNIVERSITY [CN]/[CN]
Inventors
  • 张陆勇 ZHANG, Luyong
  • 李政 LI, Zheng
  • 周宗涛 ZHOU, Zongtao
Agents
  • 南京智造力知识产权代理有限公司 NANJING IPZHI INTELLECTUAL PROPERTY AGENCY CO., LTD.
Priority Data
201910811322.729.08.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) PPAR γ/δ DUAL AGONIST, PREPARATION METHOD THEREOF AND USE THEREOF IN PREPARING A DRUG
(FR) AGONISTE DOUBLE PPAR γ/δ, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION DANS LA PRÉPARATION D'UN MÉDICAMENT
(ZH) 一类PPARγ/δ双重激动剂、其制备方法及其作为药物的用途
Abstract
(EN)
A novel PPAR γ/δ dual agonist as described in general formula (I), a preparation method thereof and an application of a pharmaceutical composition containing a derivative in the preparation of a drug for prevention and/or treatment of disorders of glucose metabolism and/or disorders of lipid metabolism. The PPAR γ/δ dual agonist has in vivo activity of lowering blood sugar, regulating blood lipids and preventing fibrosis, and may be used in the preparation of a drug for the prevention and/or treatment of illnesses related to metabolic syndromes such as diabetes mellitus, obesity, hyperlipidemia, atherosclerosis, fibrosis and fatty liver.
(FR)
L'invention concerne un nouvel agoniste double PPAR γ/δ tel que décrit dans la formule générale (I), un procédé de préparation de celui-ci et une utilisation d'une composition pharmaceutique contenant un dérivé dans la préparation d'un médicament pour la prévention et/ou le traitement de troubles du métabolisme du glucose et/ou des troubles du métabolisme des lipides. L'agoniste double PPAR γ/δ présente une activité in vivo d'abaissement du sucre sanguin, de régulation des lipides dans le sang et de prévention de la fibrose, et peut être utilisé dans la préparation d'un médicament pour la prévention et/ou le traitement de maladies associées à des syndromes métaboliques tels que le diabète sucré, l'obésité, l'hyperlipidémie, l'athérosclérose, la fibrose et le foie gras.
(ZH)
一类通式(I)所示的新型PPARγ/δ双重激动剂、其制备方法及含有该衍生物的药物组合物在制备预防或/和治疗葡萄糖代谢异常或/和脂质代谢异常疾病的药物中的用途。所述的PPARγ/δ双重激动剂具有体内降血糖活性、调节血脂及抗纤维化等作用,可应用于制备预防或/和治疗糖尿病、肥胖症、高血脂、动脉粥样硬化,纤维化及脂肪肝等代谢综合症相关疾病的药物。
Latest bibliographic data on file with the International Bureau