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1. WO2021032935 - ENZYME INHIBITORS

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Publication Number WO/2021/032935
Publication Date 25.02.2021
International Application No. PCT/GB2019/052358
International Filing Date 21.08.2019
IPC
C07D 401/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 401/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 409/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 409/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14containing three or more hetero rings
C07D 417/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14containing three or more hetero rings
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61P 25/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
06Antimigraine agents
A61P 25/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
08Antiepileptics; Anticonvulsants
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 7/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants
  • KALVISTA PHARMACEUTICALS LIMITED [GB]/[GB]
Inventors
  • CHILDS, Mitchell Lewis
  • DAVIE, Rebecca Louise
  • EDWARDS, Hannah Joy
  • EVANS, David Michael
  • HODGSON, Simon Teanby
  • MAZZACANI, Alessandro
  • CLARK, David Edward
  • HINCHLIFFE, Paul Stuart
  • BAKER, Thomas Matthew
  • SAMBROOK SMITH, Colin Peter
  • SMITH, Alun John
  • WRIGGLESWORTH, Joseph William
  • YANG, Xuezheng
Agents
  • MCGUIRE, Gillian Margaret
  • JACKSON, Richard Eric
  • COCKERTON, Bruce Roger
  • MARSHALL, Cameron John
  • GOODFELLOW, Hugh Robin
  • TUNSTALL, Christopher Stephen
  • KIRSCH, Susan Edith
  • SMALL, Gary James
  • WARNER, James Alexander
  • BRUNNER, John Michael Owen
  • CHAPMAN, Desmond Mark
  • WISE, Daniel Joseph
  • OATES, Edward Christopher
  • MCGUIRE, Gillian Margaret
  • MORRIS, Claire Louise
  • COX, Jennifer Jane
  • GEORGIOU, Matthew
  • HOLLAND, David Christopher
  • BETTRIDGE, Paul Sebastian
  • DRAGOSAVAC, Susannah Marie
  • PREISSNER, Tanja Stephanie
  • LEATHLEY, Anna Elisabeth
  • HUSBAND, Benjamin
  • DUFFIELD, Stephen
  • MACLEOD, Ian Roger
  • HOGGETT, Christopher James
  • GRABENSTEIN, Jens
  • MICHELL, Stephen Robert
  • DARBY, Richard John
  • BARRY, Isobel Amy
  • MCKINLEY, Elizabeth Anne
  • BIRCH, Matthew John
  • THEISEN, Andreas Robert
  • BETTRIDGE, Paul Sebastian
Priority Data
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ENZYME INHIBITORS
(FR) INHIBITEURS D'ENZYME
front page image
Abstract
(EN) The present invention provides compounds of formula (I) or (Ia): compositions comprising such compounds; the use of such compounds in therapy; and methods of treating patients with such compounds; wherein A, B, n, R2, R3, R4, R5, and R6 are as defined herein.
(FR) La présente invention concerne des composés de formule (I) ou (Ia), des compositions comprenant de tels composés ; l'utilisation de tels composés en thérapie ; et des méthodes de traitement de patients au moyen desdits composés. Dans les formules, A, B, n, R2, R3, R4, R5 et R6 sont tels que définis dans la description.
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