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1. WO2021030474 - ARTICLES AND METHODS FOR ADMINISTRATION OF THERAPEUTIC AGENTS

Publication Number WO/2021/030474
Publication Date 18.02.2021
International Application No. PCT/US2020/045987
International Filing Date 12.08.2020
IPC
A61K 31/375 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
375Ascorbic acid, i.e. vitamin C; Salts thereof
A61K 33/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
A61K 33/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
04Sulfur, selenium or tellurium; Compounds thereof
CPC
A61K 9/2013
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2013Organic compounds, e.g. phospholipids, fats
A61K 9/2054
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2022Organic macromolecular compounds
205Polysaccharides, e.g. alginate, gums; Cyclodextrin
2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
A61K 9/2846
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
28Dragees; Coated pills or tablets ; , e.g. with film or compression coating
2806Coating materials
2833Organic macromolecular compounds
284obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
2846Poly(meth)acrylates
A61K 9/2866
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
28Dragees; Coated pills or tablets ; , e.g. with film or compression coating
2806Coating materials
2833Organic macromolecular compounds
286Polysaccharides, e.g. gums; Cyclodextrin
2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
A61K 9/4858
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
4841Filling excipients; Inactive ingredients
4858Organic compounds
A61K 9/4866
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
4841Filling excipients; Inactive ingredients
4866Organic macromolecular compounds
Applicants
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US]/[US]
  • THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US]/[US]
Inventors
  • TRAVERSO, Carlo Giovanni
  • KORZENIK, Joshua
  • LANGER, Robert S.
  • STEIGER, Christoph Winfried Johannes
Agents
  • ZEIGER, Adam S.
  • BAKER, C., Hunter
  • AMUNDSEN, Eric, L.
  • ALAM, Saad
  • ATTISHA, Michael, J.
Priority Data
62/885,45012.08.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ARTICLES AND METHODS FOR ADMINISTRATION OF THERAPEUTIC AGENTS
(FR) ARTICLES ET MODES D'ADMINISTRATION D’AGENTS THÉRAPEUTIQUES
Abstract
(EN)
Articles and methods for delivering a therapeutic agent to a subject are described. These articles and methods may be useful, in some cases, for the delivery of therapeutic agents to the colon of a subject. In some embodiments, an article is configured to release a secretion inducing agent e.g., to stimulate the release of intestinal fluids. The article, in some embodiments, comprises a therapeutic agent such that the stimulated release of intestinal fluid increases the amount of therapeutic agent available for absorption by the colon. For example, in some embodiments, the articles and methods described herein advantageously promote increased absorption of therapeutic agents in subjects as compared to traditionally administered therapeutic agents without additional components such as a secretion inducing agent. In some embodiments, articles and methods described herein may increase the motility of the colon of a subject. The increase in contractions and movement of fluidic in the colon caused by increase motility may advantageously facilitate the dissolution or absorption of the therapeutic agent.
(FR)
La présente invention concerne des articles et des modes d’administration d’un agent thérapeutique à un sujet. Ces articles et modes peuvent être utiles, dans certains cas, pour l'administration d'agents thérapeutiques au côlon d'un sujet. Dans certains modes de réalisation, un article est conçu pour libérer un agent inducteur de sécrétion, par exemple, pour stimuler la libération de fluides intestinaux. Dans certains modes de réalisation, l'article comprend un agent thérapeutique de sorte que la libération stimulée de fluide intestinal augmente la quantité d'agent thérapeutique disponible pour l'absorption par le côlon. Par exemple, dans certains modes de réalisation, les articles et les modes de l’invention favorisent avantageusement une absorption accrue d'agents thérapeutiques chez des sujets par comparaison avec des agents thérapeutiques généralement administrés sans constituants supplémentaires tels qu'un agent inducteur de sécrétion. Dans certains modes de réalisation, les articles et les modes de l’invention peuvent augmenter la motilité du côlon d'un sujet. L'augmentation des contractions et du mouvement du fluide dans le côlon provoquée par l'augmentation de la motilité peut avantageusement faciliter la dissolution ou l'absorption de l'agent thérapeutique.
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