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1. WO2021030326 - BRUSH POLYMERS FOR THERAPEUTIC APPLICATIONS

Publication Number WO/2021/030326
Publication Date 18.02.2021
International Application No. PCT/US2020/045729
International Filing Date 11.08.2020
IPC
A61K 38/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides
A61K 47/50 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
A61K 47/64 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
CPC
A61K 2039/6031
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
60characteristics by the carrier linked to the antigen
6031Proteins
A61K 2039/6056
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
60characteristics by the carrier linked to the antigen
6031Proteins
6056Antibodies
A61K 2039/6093
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
60characteristics by the carrier linked to the antigen
6093Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
A61K 2039/627
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
62characterised by the link between antigen and carrier
627characterised by the linker
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/095
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
095Oxytocins; Vasopressins; Related peptides
Applicants
  • NORTHWESTERN UNIVERSITY [US]/[US]
Inventors
  • GIANNESCHI, Nathan C.
  • LAVINE, Jeremy A.
  • ZHANG, Bin
  • BERGER, Or
  • CHOI, Wonmin
  • WANG, Max Mu
  • BATTISTELLA, Claudia
  • SUN, Hao
Agents
  • STRICK, Benjamin F.
  • BARONE, Stephen B.
  • BURLEIGH, Michael J.
  • CHERNOMORDIK, Boris D.
  • CURTIS, Michael J.
  • CHAPMAN, Gary B.
  • SANNY, Tony
  • SULLIVAN, Sally A.
Priority Data
62/885,65512.08.2019US
63/025,38815.05.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) BRUSH POLYMERS FOR THERAPEUTIC APPLICATIONS
(FR) POLYMÈRES EN BROSSE POUR APPLICATIONS THÉRAPEUTIQUES
Abstract
(EN) In an aspect, the invention provides therapeutic agents comprising brush polymers that address challenges associated with conventional administration of free therapeutic peptides. In an embodiment, for example, the invention provides brush polymers incorporating one or more therapeutic peptides as side chain moieties. Therapeutic agents of the invention comprising brush polymers include high-density brush polymers including cross-linked brush polymers and brush block copolymers. In an embodiment, brush polymers of the invention exhibit proteolysis-resistant characteristics and maintain their biological function during formulation and administration. The invention also includes methods of making and using therapeutic agents comprising brush polymers.
(FR) Selon un aspect, l'invention concerne des agents thérapeutiques comprenant des polymères en brosse qui traitent des défis associés à l'administration classique de peptides thérapeutiques libres. Selon un mode de réalisation, par exemple, l'invention concerne des polymères en brosse incorporant un ou plusieurs peptides thérapeutiques en tant que fractions de chaîne latérale. Les agents thérapeutiques de l'invention comprenant des polymères en brosse comprennent des polymères en brosse de haute densité comprenant des polymères en brosse réticulés et des copolymères séquencés en brosse. Selon un mode de réalisation, les polymères en brosse de l'invention présentent des caractéristiques de résistance à la protéolyse et maintiennent leur fonction biologique pendant la formulation et l'administration. L'invention concerne également des procédés de fabrication et des méthodes d'utilisation d'agents thérapeutiques comprenant des polymères en brosse.
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