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1. WO2021029673 - COMPOSITION FOR INHIBITING TOXICITY OF NANOPARTICLES AND ENVIRONMENTALLY-DERIVED FINE PARTICLES

Publication Number WO/2021/029673
Publication Date 18.02.2021
International Application No. PCT/KR2020/010687
International Filing Date 12.08.2020
IPC
A61K 38/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
06Tripeptides
A61K 31/191 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
191Acyclic acids having two or more hydroxy groups, e.g. gluconic acid
A61P 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39General protective or antinoxious agents
A61K 8/64 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
64Proteins; Peptides; Derivatives or degradation products thereof
A61K 8/365 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
33containing oxygen
36Carboxylic acids; Salts or anhydrides thereof
365Hydroxycarboxylic acids; Ketocarboxylic acids
A61Q 17/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
17Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
Applicants
  • 아주대학교산학협력단 AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR]/[KR]
Inventors
  • 이광 LEE, Gwang
  • 신태환 SHIN, Tae-Hwan
  • 강엽 KANG, Yup
  • 곽종영 KWAK, Jong-Young
  • 이다연 LEE, Dayeon
Agents
  • 특허법인 태백 TAEBAEK INTELLECTUAL PROPERTY LAW FIRM
Priority Data
10-2019-009936314.08.2019KR
10-2020-009430629.07.2020KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION FOR INHIBITING TOXICITY OF NANOPARTICLES AND ENVIRONMENTALLY-DERIVED FINE PARTICLES
(FR) COMPOSITION POUR INHIBER LA TOXICITÉ DE NANOPARTICULES ET DE PARTICULES FINES PRÉSENTES DANS L'ENVIRONNEMENT
(KO) 나노입자 및 환경 유래 미세입자의 독성 저해 조성물
Abstract
(EN)
The present invention relates to a composition for inhibiting the toxicity with respect to nanoparticles and fine particles generated from the environment. Since it has been confirmed that a decrease in intracellular ATP, a decrease in cell viability, inflammation-induced morphological changes in cells and cell activation, which are induced by nanoparticles or environmentally-derived fine particles, are inhibited by means of the composition of the present invention, the composition may be utilized as a reducing substance for the toxicity of nanoparticles and fine particles.
(FR)
La présente invention concerne une composition permettant d'inhiber la toxicité par rapport à des nanoparticules et à des particules fines générées présentes dans l'environnement. Comme il a été confirmé que la composition selon la présente invention permet d'inhiber une diminution de l'ATP intracellulaire, une diminution de la viabilité cellulaire, des variations morphologiques induites par une inflammation dans les cellules et l'activation des cellules, qui sont induites par des nanoparticules ou des particules fines présentes dans l'environnement, la composition peut être utilisée en tant que substance réduisant la toxicité de nanoparticules et de particules fines.
(KO)
본 발명은 나노입자 및 환경에서 발생되는 미세입자에 대한 독성을 저해하는 조성물에 관한 것으로, 나노입자 또는 환경 유래 미세 입자로 유발된 세포 내 ATP 감소, 세포 생존율 감소, 세포의 염증 유발성 형태 변화 및 세포의 활성화가 본 발명에 따른 조성물에 의해 저해되는 것이 확인됨에 따라, 상기 조성물은 나노입자 및 미세입자의 독성에 대한 저감 물질로 유용하게 사용될 수 있는 가능성이 있다.
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