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1. WO2021018792 - OSTEOCRIN, LEBETIN OR ANP FOR DESTROYING BACTERIAL BIOFILMS

Publication Number WO/2021/018792
Publication Date 04.02.2021
International Application No. PCT/EP2020/071029
International Filing Date 24.07.2020
IPC
A61K 38/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
A61L 2/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
16using chemical substances
A61P 31/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
CPC
A61K 38/1703
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
1703from vertebrates
A61K 38/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
A61K 38/2242
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
2242Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
Applicants
  • UNIVERSITÉ DE ROUEN-NORMANDIE [FR]/[FR]
Inventors
  • LESOUHAITIER, Olivier
  • FEUILLOLEY, Marc
  • CLAMENS, Thomas
  • RODRIGUES, Sophie
  • LAURENCY, Sylvie
  • LOUIS, Mélissande
Agents
  • DOMENEGO, Bertrand
  • BLOT, Philippe
  • HABASQUE, Etienne
  • COLOMBIE, Damien
  • HOLTZ, Beatrice
  • NEYRET, Daniel
Priority Data
FR190851126.07.2019FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) OSTEOCRIN, LEBETIN OR ANP FOR DESTROYING BACTERIAL BIOFILMS
(FR) L'OSTEOCRINE, LA LEBETINE OU L'ANP POUR DETRUIRE LES BIOFILMS BACTERIENS
Abstract
(EN)
The present invention relates to a natriuretic peptide selected from the group made up of (i) osteocrin, an osteocrin propeptide or osteocrin derivative, (ii) a lebetin, a lebetin fragment, or a lebetin or lebetin fragment derivative, and (iii) an ANP peptide, ANP propeptide or ANP peptide derivative, for the use thereof in a method for therapeutically treating a bacterial infection associated with a bacterial biofilm in a subject, wherein said natriuretic peptide disperses the bacterial biofilm. In a particular embodiment, the natriuretic peptide is used in combination with an antibiotic.
(FR)
La présente invention concerne un peptide natriurétique choisi dans le groupe constitué de (i) l'ostéocrine, un propeptide d'ostéocrine ou dérivé d'ostéocrine, (ii) une lébétine, un fragment de lébétine ou un dérivé de lébétine ou d'un fragment de lébétine, et (iii) un peptide ANP, propeptide d'ANP ou dérivé de peptide ANP, pour son utilisation dans une méthode de traitement thérapeutique d'une infection bactérienne associée à un biofilm bactérien chez un sujet, dans laquelle ledit peptide natriurétique disperse ledit biofilm bactérien. Dans un mode de réalisation particulier, ledit peptide natriurétique est utilisé en combinaison avec un antibiotique.
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